TY - JOUR
T1 - Global burden of multiple sclerosis and its attributable risk factors, 1990–2019
AU - Safiri, Saeid
AU - Ghaffari Jolfayi, Amir
AU - Mousavi, Seyed Ehsan
AU - Nejadghaderi, Seyed Aria
AU - Sullman, Mark J.M.
AU - Kolahi, Ali Asghar
N1 - Publisher Copyright:
Copyright © 2024 Safiri, Ghaffari Jolfayi, Mousavi, Nejadghaderi, Sullman and Kolahi.
PY - 2024
Y1 - 2024
N2 - Background: Multiple sclerosis (MS) is a progressively debilitating disorder that has seen a notable rise in prevalence in recent years. This study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries and territories. Methods: Data on the prevalence, death and disability-adjusted life years (DALYs) attributable to MS were obtained from the publically available Global Burden of Disease 2019 project. The estimates are reported as numbers, percentages, and age-standardized rates per 100,000, accompanied by 95% uncertainty intervals. Results: In 2019, MS accounted for 1.8 million prevalent cases, 22.4 thousand deaths and 1.2 million DALYs worldwide. There were significant declines in the global age-standardized prevalence, mortality and DALY rates of MS over the period 1990–2019. In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. At the regional level, a non-linear relationship was observed between the age-standardized DALY rate of MS and SDI. Conclusion: Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable number of DALYs and prevalent cases. Integrating MS and its associated risk factors into healthcare planning is vital, especially in areas with high levels of socioeconomic development.
AB - Background: Multiple sclerosis (MS) is a progressively debilitating disorder that has seen a notable rise in prevalence in recent years. This study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries and territories. Methods: Data on the prevalence, death and disability-adjusted life years (DALYs) attributable to MS were obtained from the publically available Global Burden of Disease 2019 project. The estimates are reported as numbers, percentages, and age-standardized rates per 100,000, accompanied by 95% uncertainty intervals. Results: In 2019, MS accounted for 1.8 million prevalent cases, 22.4 thousand deaths and 1.2 million DALYs worldwide. There were significant declines in the global age-standardized prevalence, mortality and DALY rates of MS over the period 1990–2019. In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. At the regional level, a non-linear relationship was observed between the age-standardized DALY rate of MS and SDI. Conclusion: Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable number of DALYs and prevalent cases. Integrating MS and its associated risk factors into healthcare planning is vital, especially in areas with high levels of socioeconomic development.
KW - death
KW - disability adjusted life years
KW - global
KW - multiple sclerosis
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85208962810&partnerID=8YFLogxK
U2 - 10.3389/fneur.2024.1448377
DO - 10.3389/fneur.2024.1448377
M3 - Article
AN - SCOPUS:85208962810
SN - 1664-2295
VL - 15
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1448377
ER -