Glycosidases in bloodstream forms of Trypanosoma brucei brucei

Mark Carroll, Peter McCrorie

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. 1. Nine glycosidases in bloodstream forms of Trypanosoma brucei brucei S42 were partially characterised. 2. 2. α-Glucosidase had similar physicochemical and enzymic properties to those of α-galactosidase, β-glucosidase, N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase. 3. 3. α-Mannosidase was clearly distinct from the other glycosidases with respect to pH optimum, thermostability, specific activity during the course of parasitaemia, and subcellular location. 4. 4. The glycosidases studied here may play a role in the turnover of trypanosomal glycoproteins, in particular the variant-specific surface antigen.

Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume67
Issue number4
DOIs
Publication statusPublished - 1980

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Trypanosoma brucei brucei
Glycoside Hydrolases
Glucosidases
Hexosaminidases
Mannosidases
Galactosidases
Parasitemia
Surface Antigens
Glycoproteins

Cite this

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abstract = "1. 1. Nine glycosidases in bloodstream forms of Trypanosoma brucei brucei S42 were partially characterised. 2. 2. α-Glucosidase had similar physicochemical and enzymic properties to those of α-galactosidase, β-glucosidase, N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase. 3. 3. α-Mannosidase was clearly distinct from the other glycosidases with respect to pH optimum, thermostability, specific activity during the course of parasitaemia, and subcellular location. 4. 4. The glycosidases studied here may play a role in the turnover of trypanosomal glycoproteins, in particular the variant-specific surface antigen.",
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Glycosidases in bloodstream forms of Trypanosoma brucei brucei. / Carroll, Mark; McCrorie, Peter.

In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Vol. 67, No. 4, 1980, p. 685-688.

Research output: Contribution to journalArticle

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AB - 1. 1. Nine glycosidases in bloodstream forms of Trypanosoma brucei brucei S42 were partially characterised. 2. 2. α-Glucosidase had similar physicochemical and enzymic properties to those of α-galactosidase, β-glucosidase, N-acetyl-β-glucosaminidase and N-acetyl-β-galactosaminidase. 3. 3. α-Mannosidase was clearly distinct from the other glycosidases with respect to pH optimum, thermostability, specific activity during the course of parasitaemia, and subcellular location. 4. 4. The glycosidases studied here may play a role in the turnover of trypanosomal glycoproteins, in particular the variant-specific surface antigen.

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