Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient

Alexandra Alexopoulou, Gerasimos Baltayiannis, Saffie Jammeh, Jenny Waters, Spyros P. Dourakis, Peter Karayiannis

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.

Original languageEnglish
Pages (from-to)2861-2865
Number of pages5
JournalJournal of Clinical Microbiology
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 2004

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