TY - JOUR
T1 - Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient
AU - Alexopoulou, Alexandra
AU - Baltayiannis, Gerasimos
AU - Jammeh, Saffie
AU - Waters, Jenny
AU - Dourakis, Spyros P.
AU - Karayiannis, Peter
PY - 2004/6
Y1 - 2004/6
N2 - A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.
AB - A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.
UR - https://www.scopus.com/pages/publications/2942590577
U2 - 10.1128/JCM.42.6.2861-2865.2004
DO - 10.1128/JCM.42.6.2861-2865.2004
M3 - Article
C2 - 15184493
AN - SCOPUS:2942590577
SN - 0095-1137
VL - 42
SP - 2861
EP - 2865
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 6
ER -
