Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient

S. Seddigh-Tonekaboni; W. L. Lim; B. Young; J. L. Hou; J. Waters; K. X. Luo; H. C. Thomas; P. Karayiannis

doi:10.1046/j.1365-2893.2001.00275.x

Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient

S. Seddigh-Tonekaboni
, W. L. Lim
, B. Young
, J. L. Hou
, J. Waters
, K. X. Luo
, H. C. Thomas
, P. Karayiannis

Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Variants of hepatitis B virus (HBV), with amino acid substitutions in the major antigenic "a" determinant of hepatitis B surface antigen (HBsAg), have been described mainly in vaccinated children. In the present study in addition to vaccinated children, we have investigated Chinese blood donors positive for anti-HBc alone, and a patient with continuing liver disease after interferon-induced seroconversion to anti-HBs. Variants were detected in two of four children with break-through infections. One child had a double mutation (P142S and G145R) and the other a G145A substitution. Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D). The present results indicate that HBsAg variants may exist in individuals other than vaccinated children.

Original language	English
Pages (from-to)	154-158
Number of pages	5
Journal	Journal of Viral Hepatitis
Volume	8
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2893.2001.00275.x
Publication status	Published - 2001

Keywords

HBsAg variants
Interferon
Vaccinees

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2893.2001.00275.x

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title = "Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient",

abstract = "Variants of hepatitis B virus (HBV), with amino acid substitutions in the major antigenic {"}a{"} determinant of hepatitis B surface antigen (HBsAg), have been described mainly in vaccinated children. In the present study in addition to vaccinated children, we have investigated Chinese blood donors positive for anti-HBc alone, and a patient with continuing liver disease after interferon-induced seroconversion to anti-HBs. Variants were detected in two of four children with break-through infections. One child had a double mutation (P142S and G145R) and the other a G145A substitution. Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D). The present results indicate that HBsAg variants may exist in individuals other than vaccinated children.",

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doi = "10.1046/j.1365-2893.2001.00275.x",

language = "English",

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pages = "154--158",

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T1 - Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient

AU - Seddigh-Tonekaboni, S.

AU - Lim, W. L.

AU - Young, B.

AU - Hou, J. L.

AU - Waters, J.

AU - Luo, K. X.

AU - Thomas, H. C.

AU - Karayiannis, P.

PY - 2001

Y1 - 2001

N2 - Variants of hepatitis B virus (HBV), with amino acid substitutions in the major antigenic "a" determinant of hepatitis B surface antigen (HBsAg), have been described mainly in vaccinated children. In the present study in addition to vaccinated children, we have investigated Chinese blood donors positive for anti-HBc alone, and a patient with continuing liver disease after interferon-induced seroconversion to anti-HBs. Variants were detected in two of four children with break-through infections. One child had a double mutation (P142S and G145R) and the other a G145A substitution. Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D). The present results indicate that HBsAg variants may exist in individuals other than vaccinated children.

AB - Variants of hepatitis B virus (HBV), with amino acid substitutions in the major antigenic "a" determinant of hepatitis B surface antigen (HBsAg), have been described mainly in vaccinated children. In the present study in addition to vaccinated children, we have investigated Chinese blood donors positive for anti-HBc alone, and a patient with continuing liver disease after interferon-induced seroconversion to anti-HBs. Variants were detected in two of four children with break-through infections. One child had a double mutation (P142S and G145R) and the other a G145A substitution. Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D). The present results indicate that HBsAg variants may exist in individuals other than vaccinated children.

KW - HBsAg variants

KW - Interferon

KW - Vaccinees

UR - https://www.scopus.com/pages/publications/0035076688

U2 - 10.1046/j.1365-2893.2001.00275.x

DO - 10.1046/j.1365-2893.2001.00275.x

M3 - Article

C2 - 11264736

AN - SCOPUS:0035076688

SN - 1352-0504

VL - 8

SP - 154

EP - 158

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

IS - 2

ER -

Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient

Abstract

Keywords

UN SDGs

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