Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread

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13 Citations (Scopus)

Abstract

Hepatitis B virus is a member of the Hepadnaviridae family and responsible for causing acute and chronic hepatitis in humans. The current estimates of people chronically infected with the virus are put at 250 million worldwide. Immune-mediated liver damage in these individuals may lead to the development of cirrhosis and hepatocellular carcinoma later in life. This review deals with our current understanding of the virology, molecular biology, life cycle and cell-to-cell spread of this very important pathogen, all of which are considered essential for current and future approaches to antiviral treatment.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalHepatology International
DOIs
Publication statusAccepted/In press - 2 Nov 2017

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Virology
Life Cycle Stages
Hepatitis B virus
Molecular Biology
Hepadnaviridae
Chronic Hepatitis
Antiviral Agents
Hepatocellular Carcinoma
Fibrosis
Viruses
Liver

Keywords

  • Cell-to-cell spread
  • Genotypes
  • Hepatitis B virus
  • Life cycle
  • Molecular virology
  • Replication

Cite this

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