Abstract
In order to type 45 recent isolates of Hepatitis C virus (HCV) originating from four different geographic regions of the world, we performed phylogenetic analysis of a 192 nucleotides (nts) long sequence from the 5′non-coding region (5′-NCR) of the virus genome and compared them with 55 HCV isolates/strains of known type. The results of this study showed that phylogenetic studies can assign an HCV isolate to the correct type in 100% and to the correct subtype in 98%. A comparison of this method with other methods using commercial kits revealed that it is appropriate for clinical use and is cost effective.
| Original language | English |
|---|---|
| Pages (from-to) | 179-182 |
| Number of pages | 4 |
| Journal | Acta Virologica |
| Volume | 46 |
| Issue number | 3 |
| Publication status | Published - 2002 |
Keywords
- Genetic variability
- Genotypes
- Hepatitis C virus
- Phylogenetic tree analysis
- Virus typing
