TY - JOUR
T1 - HLA-B27 in the Greek Cypriot population
T2 - Distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707
AU - Varnavidou-Nicolaidou, Agathi
AU - Karpasitou, Katerina
AU - Georgiou, Dora
AU - Stylianou, Galatia
AU - Kokkofitou, Avgousta
AU - Michalis, Christodoulides
AU - Constantina, Constantinou
AU - Gregoriadou, Christiana
AU - Kyriakides, George
PY - 2004/12
Y1 - 2004/12
N2 - The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek Cypriot population. We selected 102 HLA-B27-positive individuals (60 controls and 42 patients). Typing of the HLA-B27 alleles was performed by polymerase chain reaction amplification with sequence-specific primers. Only two alleles were detected in the patient group: B*2702 (n = 31, 73.8%) and B*2705 (n = 11, 26.2%). The HLA-B*2707 allele was detected (n = 10, 16.7%) only in the healthy controls in addition to the B*2702 (n = 31, 51.7%) and B*2705 (n = 19, 31.7%) alleles. Our results show a restricted number of HLA-B27 subtypes associated with AS and other B27-related diseases and an elevated frequency of the B*2702 allele in the AS patients. The allele B*2707 seems to have a protective role in the population studied because it was found only in the healthy controls.
AB - The major purpose of the present study was to investigate the frequency of human leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek Cypriot population. We selected 102 HLA-B27-positive individuals (60 controls and 42 patients). Typing of the HLA-B27 alleles was performed by polymerase chain reaction amplification with sequence-specific primers. Only two alleles were detected in the patient group: B*2702 (n = 31, 73.8%) and B*2705 (n = 11, 26.2%). The HLA-B*2707 allele was detected (n = 10, 16.7%) only in the healthy controls in addition to the B*2702 (n = 31, 51.7%) and B*2705 (n = 19, 31.7%) alleles. Our results show a restricted number of HLA-B27 subtypes associated with AS and other B27-related diseases and an elevated frequency of the B*2702 allele in the AS patients. The allele B*2707 seems to have a protective role in the population studied because it was found only in the healthy controls.
KW - ankylosing spondylitis
KW - HLA-B27 subtypes
KW - protective allele
UR - http://www.scopus.com/inward/record.url?scp=10444251006&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2004.08.177
DO - 10.1016/j.humimm.2004.08.177
M3 - Article
C2 - 15603872
AN - SCOPUS:10444251006
SN - 0198-8859
VL - 65
SP - 1451
EP - 1454
JO - Human Immunology
JF - Human Immunology
IS - 12
ER -