Hormone replacement therapy and cardiovascular disease: What went wrong and where do we go from here?

Raghvendra K. Dubey, Bruno Imthurn, Lefteris C. Zacharia, Edwin K. Jackson

Research output: Contribution to journalShort survey

64 Citations (Scopus)

Abstract

Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone's astonishment, the Women's Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?

Original languageEnglish
Pages (from-to)789-795
Number of pages7
JournalHypertension
Volume44
Issue number6
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Cardiovascular diseases
  • Estrogen
  • Hormones

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