Hormone replacement therapy and cardiovascular disease: What went wrong and where do we go from here?

Raghvendra K. Dubey; Bruno Imthurn; Lefteris C. Zacharia; Edwin K. Jackson

doi:10.1161/01.HYP.0000145988.95551.28

Hormone replacement therapy and cardiovascular disease: What went wrong and where do we go from here?

Raghvendra K. Dubey, Bruno Imthurn, Lefteris C. Zacharia, Edwin K. Jackson

School of Life and Health Sciences

Research output: Contribution to journal › Short survey › peer-review

Abstract

Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone's astonishment, the Women's Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?

Original language	English
Pages (from-to)	789-795
Number of pages	7
Journal	Hypertension
Volume	44
Issue number	6
DOIs	https://doi.org/10.1161/01.HYP.0000145988.95551.28
Publication status	Published - Dec 2004

Keywords

Cardiovascular diseases
Estrogen
Hormones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/01.HYP.0000145988.95551.28

Cite this

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title = "Hormone replacement therapy and cardiovascular disease: What went wrong and where do we go from here?",

abstract = "Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone's astonishment, the Women's Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?",

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AU - Jackson, Edwin K.

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AB - Observational studies in humans and experimental studies in animals and isolated cells supported the widely held belief that hormone replacement therapy protects the cardiovascular system from disease. To nearly everyone's astonishment, the Women's Health Initiative Study and the Heart and Estrogen/Progestin Replacement Study overturned the conclusion that hormone replacement therapy protects the cardiovascular system and, in fact, supported the opposite view that such therapy may actually increase the risk of cardiovascular disease. This review addresses 2 questions: what went wrong and where do we go from here?

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KW - Estrogen

KW - Hormones

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Hormone replacement therapy and cardiovascular disease: What went wrong and where do we go from here?

Abstract

Keywords

UN SDGs

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