Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

for the PRIORITISE Study Investigators

doi:10.1093/ofid/ofac526

Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

for the PRIORITISE Study Investigators

Research output: Contribution to journal › Article › peer-review

Abstract

Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

Original language	English
Article number	ofac526
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofac526
Publication status	Published - 1 Oct 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
host biomarker
prognosis

Access to Document

10.1093/ofid/ofac526

Cite this

@article{f730d4b77afc4ba1b004ad34e6b93786,

title = "Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study",

abstract = "Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.",

keywords = "COVID-19, host biomarker, prognosis",

author = "\{for the PRIORITISE Study Investigators\} and Arjun Chandna and Raman Mahajan and Priyanka Gautam and Lazaro Mwandigha and Pragya Kumar and Varghese, \{George M.\} and Constantinos Koshiaris and Yoel Lubell and Sakib Burza",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2022",

month = oct,

day = "1",

doi = "10.1093/ofid/ofac526",

language = "English",

volume = "9",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "10",

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TY - JOUR

T1 - Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019

T2 - A Prospective Cohort Study

AU - for the PRIORITISE Study Investigators

AU - Chandna, Arjun

AU - Mahajan, Raman

AU - Gautam, Priyanka

AU - Mwandigha, Lazaro

AU - Kumar, Pragya

AU - Varghese, George M.

AU - Koshiaris, Constantinos

AU - Lubell, Yoel

AU - Burza, Sakib

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

AB - Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

KW - COVID-19

KW - host biomarker

KW - prognosis

UR - https://www.scopus.com/pages/publications/85145089484

U2 - 10.1093/ofid/ofac526

DO - 10.1093/ofid/ofac526

M3 - Article

AN - SCOPUS:85145089484

SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 10

M1 - ofac526

ER -

Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

Abstract

UN SDGs

Keywords

Access to Document

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