Identification of seven novel mutations in LH β-subunit gene by SSCP

Ashim C. Roy, Wu Xiang Liao, Ying Chen, Sabaratnam Arulkumaran, Shan S. Ratnam

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Seven new point mutations have been identified from LH β-subunit gene by PCR-mediated SSCP, and sequencing. One mutation was found changing amino acid from Gln102 to Ser102. The remaining six mutations, which did not change the codings, were in complete linkage disequilibrium. SSCP can be used in the diagnosis of LH-related disorders.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalMolecular and Cellular Biochemistry
Volume165
Issue number2
Publication statusPublished - 1996

Keywords

  • Luteinizing hormone
  • Mutation
  • Polymerase chain reaction
  • Restriction enzyme analysis
  • Sequencing
  • Single-stranded conformation polymorphism (SSCP)

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