Immune response of patients with congenital coagulation disorders to hepatitis b vaccine: Suboptimal response and human immunodeficiency virus infection

Elizabeth J. Miller, Christine A. Lee, Sue Holmes, P. B.A. Kernoff, H. C. Thomas, P. Karayiannis

Research output: Contribution to journalEditorial

14 Citations (Scopus)

Abstract

Seventy‐eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90%) anti‐HIV‐negative adults vaccinated subcutaneously and 14/25 (56%) anti‐HIV‐negative adults vaccinated intradermally showed an immune response. At 24 months, the anti‐HBs level was > 10 IU/I in all children vaccinated subcutaneously, 83% of children vaccinated intradermally, 77% of adults vaccinated subcutaneously, and 55% of adults vaccinated intradermally. Eight of 15 (53%) adult patients who were anti‐HIV positive were also anti‐HBc positive before vaccination and 6/8 (75%) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti‐HBs levels and appropriate boosting is recommended.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalJournal of Medical Virology
Volume28
Issue number2
DOIs
Publication statusPublished - 1989

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Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Virus Diseases
Hepatitis
Vaccines
HIV
Vaccination
Hepatitis B Vaccines

Keywords

  • haemophilia
  • HIV
  • plasma‐derived hepatitis B vaccine

Cite this

Miller, Elizabeth J. ; Lee, Christine A. ; Holmes, Sue ; Kernoff, P. B.A. ; Thomas, H. C. ; Karayiannis, P. / Immune response of patients with congenital coagulation disorders to hepatitis b vaccine : Suboptimal response and human immunodeficiency virus infection. In: Journal of Medical Virology. 1989 ; Vol. 28, No. 2. pp. 96-100.
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abstract = "Seventy‐eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90{\%}) anti‐HIV‐negative adults vaccinated subcutaneously and 14/25 (56{\%}) anti‐HIV‐negative adults vaccinated intradermally showed an immune response. At 24 months, the anti‐HBs level was > 10 IU/I in all children vaccinated subcutaneously, 83{\%} of children vaccinated intradermally, 77{\%} of adults vaccinated subcutaneously, and 55{\%} of adults vaccinated intradermally. Eight of 15 (53{\%}) adult patients who were anti‐HIV positive were also anti‐HBc positive before vaccination and 6/8 (75{\%}) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti‐HBs levels and appropriate boosting is recommended.",
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Immune response of patients with congenital coagulation disorders to hepatitis b vaccine : Suboptimal response and human immunodeficiency virus infection. / Miller, Elizabeth J.; Lee, Christine A.; Holmes, Sue; Kernoff, P. B.A.; Thomas, H. C.; Karayiannis, P.

In: Journal of Medical Virology, Vol. 28, No. 2, 1989, p. 96-100.

Research output: Contribution to journalEditorial

TY - JOUR

T1 - Immune response of patients with congenital coagulation disorders to hepatitis b vaccine

T2 - Suboptimal response and human immunodeficiency virus infection

AU - Miller, Elizabeth J.

AU - Lee, Christine A.

AU - Holmes, Sue

AU - Kernoff, P. B.A.

AU - Thomas, H. C.

AU - Karayiannis, P.

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AB - Seventy‐eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90%) anti‐HIV‐negative adults vaccinated subcutaneously and 14/25 (56%) anti‐HIV‐negative adults vaccinated intradermally showed an immune response. At 24 months, the anti‐HBs level was > 10 IU/I in all children vaccinated subcutaneously, 83% of children vaccinated intradermally, 77% of adults vaccinated subcutaneously, and 55% of adults vaccinated intradermally. Eight of 15 (53%) adult patients who were anti‐HIV positive were also anti‐HBc positive before vaccination and 6/8 (75%) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti‐HBs levels and appropriate boosting is recommended.

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