Impact of ethanol on the developing GABAergic system

Ricardo Noboro Isayama, Paulo Emilio Correa Leite, Jean Pierre Mendes Lima, Daniela Uziel, Edna Nanami Yamasaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.

Original languageEnglish
Pages (from-to)1922-1939
Number of pages18
JournalAnatomical Record
Volume292
Issue number12
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Cortical neurons
  • Developing brain
  • GABA
  • Ganglionic eminence
  • Prenatal ethanol exposure

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    Isayama, R. N., Leite, P. E. C., Lima, J. P. M., Uziel, D., & Yamasaki, E. N. (2009). Impact of ethanol on the developing GABAergic system. Anatomical Record, 292(12), 1922-1939. https://doi.org/10.1002/ar.20966