Impact of ethanol on the developing GABAergic system

Ricardo Noboro Isayama; Paulo Emilio Correa Leite; Jean Pierre Mendes Lima; Daniela Uziel; Edna Nanami Yamasaki

doi:10.1002/ar.20966

Impact of ethanol on the developing GABAergic system

Ricardo Noboro Isayama, Paulo Emilio Correa Leite, Jean Pierre Mendes Lima, Daniela Uziel, Edna Nanami Yamasaki

Research output: Contribution to journal › Article › peer-review

Abstract

Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.

Original language	English
Pages (from-to)	1922-1939
Number of pages	18
Journal	Anatomical Record
Volume	292
Issue number	12
DOIs	https://doi.org/10.1002/ar.20966
Publication status	Published - Dec 2009

Keywords

Cortical neurons
Developing brain
GABA
Ganglionic eminence
Prenatal ethanol exposure

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title = "Impact of ethanol on the developing GABAergic system",

abstract = "Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.",

keywords = "Cortical neurons, Developing brain, GABA, Ganglionic eminence, Prenatal ethanol exposure",

author = "Isayama, {Ricardo Noboro} and Leite, {Paulo Emilio Correa} and Lima, {Jean Pierre Mendes} and Daniela Uziel and Yamasaki, {Edna Nanami}",

year = "2009",

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doi = "10.1002/ar.20966",

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AU - Leite, Paulo Emilio Correa

AU - Lima, Jean Pierre Mendes

AU - Uziel, Daniela

AU - Yamasaki, Edna Nanami

PY - 2009/12

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KW - Cortical neurons

KW - Developing brain

KW - GABA

KW - Ganglionic eminence

KW - Prenatal ethanol exposure

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JO - Anatomical Record

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Impact of ethanol on the developing GABAergic system

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