TY - JOUR
T1 - In-vitro activity of monobactam, SQ 26, 776, against Gram-negative bacteria
AU - Percival, A.
AU - Thomas, E.
AU - Hart, C. A.
AU - Karayiannis, P.
PY - 1981
Y1 - 1981
N2 - SQ 26, 776 (SQ), a new monocyclic I-lactam, has considerable in-vitro activity against gonococci and a great variety of enterobacteria, in particular multiply-resistant clinical isolates. This activity is similar to that of new cephalosporins. Rare strains of klebsiella exist which are relatively insensitive because they possess I-lactamases, which inactivate both SQ and many of the new cephalosporins. Activity against Pseudomonas aeruginosa and Bacteroides fragilis was relatively less in that order, for a small minority of the latter again due to I-lactamase activity.
AB - SQ 26, 776 (SQ), a new monocyclic I-lactam, has considerable in-vitro activity against gonococci and a great variety of enterobacteria, in particular multiply-resistant clinical isolates. This activity is similar to that of new cephalosporins. Rare strains of klebsiella exist which are relatively insensitive because they possess I-lactamases, which inactivate both SQ and many of the new cephalosporins. Activity against Pseudomonas aeruginosa and Bacteroides fragilis was relatively less in that order, for a small minority of the latter again due to I-lactamase activity.
UR - http://www.scopus.com/inward/record.url?scp=0019780812&partnerID=8YFLogxK
U2 - 10.1093/jac/8.suppl_E.49
DO - 10.1093/jac/8.suppl_E.49
M3 - Article
C2 - 6799482
AN - SCOPUS:0019780812
SN - 0305-7453
VL - 8
SP - 49
EP - 55
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
ER -