In-vitro activity of monobactam, SQ 26, 776, against Gram-negative bacteria

A. Percival, E. Thomas, C. A. Hart, P. Karayiannis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

SQ 26, 776 (SQ), a new monocyclic I-lactam, has considerable in-vitro activity against gonococci and a great variety of enterobacteria, in particular multiply-resistant clinical isolates. This activity is similar to that of new cephalosporins. Rare strains of klebsiella exist which are relatively insensitive because they possess I-lactamases, which inactivate both SQ and many of the new cephalosporins. Activity against Pseudomonas aeruginosa and Bacteroides fragilis was relatively less in that order, for a small minority of the latter again due to I-lactamase activity.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume8
DOIs
Publication statusPublished - 1981

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Monobactams
Aztreonam
Cephalosporins
Gram-Negative Bacteria
Lactams
Bacteroides fragilis
Klebsiella
Neisseria gonorrhoeae
Enterobacteriaceae
Pseudomonas aeruginosa
In Vitro Techniques

Cite this

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abstract = "SQ 26, 776 (SQ), a new monocyclic I-lactam, has considerable in-vitro activity against gonococci and a great variety of enterobacteria, in particular multiply-resistant clinical isolates. This activity is similar to that of new cephalosporins. Rare strains of klebsiella exist which are relatively insensitive because they possess I-lactamases, which inactivate both SQ and many of the new cephalosporins. Activity against Pseudomonas aeruginosa and Bacteroides fragilis was relatively less in that order, for a small minority of the latter again due to I-lactamase activity.",
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In-vitro activity of monobactam, SQ 26, 776, against Gram-negative bacteria. / Percival, A.; Thomas, E.; Hart, C. A.; Karayiannis, P.

In: Journal of Antimicrobial Chemotherapy, Vol. 8, 1981, p. 49-55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In-vitro activity of monobactam, SQ 26, 776, against Gram-negative bacteria

AU - Percival, A.

AU - Thomas, E.

AU - Hart, C. A.

AU - Karayiannis, P.

PY - 1981

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