In-vitro activity of monobactam, SQ 26, 776, against Gram-negative bacteria

A. Percival, E. Thomas, C. A. Hart, P. Karayiannis

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


SQ 26, 776 (SQ), a new monocyclic I-lactam, has considerable in-vitro activity against gonococci and a great variety of enterobacteria, in particular multiply-resistant clinical isolates. This activity is similar to that of new cephalosporins. Rare strains of klebsiella exist which are relatively insensitive because they possess I-lactamases, which inactivate both SQ and many of the new cephalosporins. Activity against Pseudomonas aeruginosa and Bacteroides fragilis was relatively less in that order, for a small minority of the latter again due to I-lactamase activity.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Publication statusPublished - 1981


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