TY - JOUR
T1 - Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction
AU - Felekkis, Kyriakos
AU - Voskarides, Konstantinos
AU - Dweep, Harsh
AU - Sticht, Carsten
AU - Gretz, Norbert
AU - Deltas, Constantinos
PY - 2011/9
Y1 - 2011/9
N2 - MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.
AB - MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.
UR - http://www.scopus.com/inward/record.url?scp=80052150067&partnerID=8YFLogxK
U2 - 10.1093/molbev/msr078
DO - 10.1093/molbev/msr078
M3 - Article
C2 - 21441354
AN - SCOPUS:80052150067
SN - 0737-4038
VL - 28
SP - 2421
EP - 2424
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 9
ER -