Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction

Kyriakos Felekkis, Konstantinos Voskarides, Harsh Dweep, Carsten Sticht, Norbert Gretz, Constantinos Deltas

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.

Original languageEnglish
Pages (from-to)2421-2424
Number of pages4
JournalMolecular Biology and Evolution
Volume28
Issue number9
DOIs
Publication statusPublished - Sep 2011

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