Infertility: Recurrent gestational trophoblastic disease following in-vitro fertilization

V. Tanos, D. Meirow, B. E. Reubinoff, S. O. Anteby

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14 Citations (Scopus)


Recurrence of gestational trophoblastic disease (GTD) following two attempts at in-vitro fertilization (IVF)/embryo transfer is reported in a childless couple after 17 years of unsuccessful trials of ovulation induction. The diagnosis of bilateral tubal obstruction was finally established, indicating IVF treatment. After the first IVF/embryo transfer treatment, the woman developed GTD and was treated with methotrexate. After a second IVF attempt, GTD was again diagnosed. This time there was no response to methotrexate, thus necessitating second-line chemotherapy. Etoposide, methotrexate, actinomycin D, cyclophosphamide, oncovine was used, and after only four treatment cycles the β-human chorionic gonadotrophin (HCG) dropped to <5 mlU/ml. After 26 months of follow-up, the β-HCG continues to be undetectable. Preimplantation evaluation and ovum donation are described as measures to minimize the risk for GTD recurrence in a future IVF/embryo transfer.

Original languageEnglish
Pages (from-to)2010-2013
Number of pages4
JournalHuman Reproduction
Issue number11
Publication statusPublished - 1994


  • EMACO treatment
  • Gestational trophoblastic disease
  • IVF-embryo transfer
  • Methotrexate treatment


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