Abstract
Recurrence of gestational trophoblastic disease (GTD) following two attempts at in-vitro fertilization (IVF)/embryo transfer is reported in a childless couple after 17 years of unsuccessful trials of ovulation induction. The diagnosis of bilateral tubal obstruction was finally established, indicating IVF treatment. After the first IVF/embryo transfer treatment, the woman developed GTD and was treated with methotrexate. After a second IVF attempt, GTD was again diagnosed. This time there was no response to methotrexate, thus necessitating second-line chemotherapy. Etoposide, methotrexate, actinomycin D, cyclophosphamide, oncovine was used, and after only four treatment cycles the β-human chorionic gonadotrophin (HCG) dropped to <5 mlU/ml. After 26 months of follow-up, the β-HCG continues to be undetectable. Preimplantation evaluation and ovum donation are described as measures to minimize the risk for GTD recurrence in a future IVF/embryo transfer.
Original language | English |
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Pages (from-to) | 2010-2013 |
Number of pages | 4 |
Journal | Human Reproduction |
Volume | 9 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1994 |
Keywords
- EMACO treatment
- Gestational trophoblastic disease
- IVF-embryo transfer
- Methotrexate treatment