Inositol levels in post mortem brain samples of Alzheimer's patients

Galila Agam; Hady Shimon; Joseph Shapiro; Michael Davidson; Varham Haroutunian

doi:10.1016/S0278-5846(98)00079-7

Inositol levels in post mortem brain samples of Alzheimer's patients

Galila Agam
, Hady Shimon
, Joseph Shapiro
, Michael Davidson
, Varham Haroutunian

Research output: Contribution to journal › Article › peer-review

Abstract

1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10-35% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC).

Original language	English
Pages (from-to)	1241-1250
Number of pages	10
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/S0278-5846(98)00079-7
Publication status	Published - Nov 1998
Externally published	Yes

Keywords

Alzheimer's disease
Brain
Inositol
Post mortem

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10.1016/S0278-5846(98)00079-7

Cite this

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title = "Inositol levels in post mortem brain samples of Alzheimer's patients",

abstract = "1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10-35\% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. The present study shows non-significant trends of 13\% increase in frontal cortex and 5\% and 21\% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC).",

keywords = "Alzheimer's disease, Brain, Inositol, Post mortem",

author = "Galila Agam and Hady Shimon and Joseph Shapiro and Michael Davidson and Varham Haroutunian",

year = "1998",

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doi = "10.1016/S0278-5846(98)00079-7",

language = "English",

volume = "22",

pages = "1241--1250",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

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T1 - Inositol levels in post mortem brain samples of Alzheimer's patients

AU - Agam, Galila

AU - Shimon, Hady

AU - Shapiro, Joseph

AU - Davidson, Michael

AU - Haroutunian, Varham

PY - 1998/11

Y1 - 1998/11

N2 - 1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10-35% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC).

AB - 1. Free inositol levels in occipital and parietal cortex of Alzheimer's Disease (AD) patients were reported to be significantly elevated by 10-35% compared with matched controls, studied by magnetic resonance spectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls. 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebellum respectively, in post mortem brain specimens of AD patients measured gas chromatographically (GC).

KW - Alzheimer's disease

KW - Brain

KW - Inositol

KW - Post mortem

UR - https://www.scopus.com/pages/publications/0032213848

U2 - 10.1016/S0278-5846(98)00079-7

DO - 10.1016/S0278-5846(98)00079-7

M3 - Article

AN - SCOPUS:0032213848

SN - 0278-5846

VL - 22

SP - 1241

EP - 1250

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 8

ER -

Inositol levels in post mortem brain samples of Alzheimer's patients

Abstract

Keywords

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