TY - JOUR
T1 - Interaction of cationic phosphorus dendrimers (CPD) with charged and neutral lipid membranes
AU - Ionov, Maksim
AU - Gardikis, Konstantinos
AU - Wróbel, Dominika
AU - Hatziantoniou, Sophia
AU - Mourelatou, Helena
AU - Majoral, Jean Pierre
AU - Klajnert, Barbara
AU - Bryszewska, Maria
AU - Demetzos, Costas
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Despite the rapid development of modern pharmaceutics, delivery of drugs to sites of action is not always effective. The research on new targeting delivery systems of pharmacologically active molecules is of great importance.Surface properties such as surface charge of drug delivery particles frequently define their pharmacokinetic profile; hence the efficiency of drugs can be increased by application of nanoparticles having appropriate surface properties.The aim of the present work was to study the interactions of cationic phosphorus-containing dendrimers (CPD) with model lipid membranes with no charge or bearing surface charge. The interactions of two generations of phosphorus dendrimers on the thermotropic behavior of model lipid membranes composed of DMPC (uncharged) or DMPC/DPPG (negatively charged) were studied using differential scanning calorimetry (DSC). The results of this study showed that CPDs can alter the thermotropic behaviour of the bilayer by reducing the cooperativity of phospholipids and this effect strongly depends on membrane surface charge. The information resulting from this study may be applied to the rational design of new drug carriers combining liposomal and dendrimeric technology.
AB - Despite the rapid development of modern pharmaceutics, delivery of drugs to sites of action is not always effective. The research on new targeting delivery systems of pharmacologically active molecules is of great importance.Surface properties such as surface charge of drug delivery particles frequently define their pharmacokinetic profile; hence the efficiency of drugs can be increased by application of nanoparticles having appropriate surface properties.The aim of the present work was to study the interactions of cationic phosphorus-containing dendrimers (CPD) with model lipid membranes with no charge or bearing surface charge. The interactions of two generations of phosphorus dendrimers on the thermotropic behavior of model lipid membranes composed of DMPC (uncharged) or DMPC/DPPG (negatively charged) were studied using differential scanning calorimetry (DSC). The results of this study showed that CPDs can alter the thermotropic behaviour of the bilayer by reducing the cooperativity of phospholipids and this effect strongly depends on membrane surface charge. The information resulting from this study may be applied to the rational design of new drug carriers combining liposomal and dendrimeric technology.
KW - DSC
KW - Liposome-dendrimer interactions
KW - Model lipid membranes
KW - Phosphorus-containing dendrimers
KW - Surface charge
UR - http://www.scopus.com/inward/record.url?scp=77957666946&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2010.07.046
DO - 10.1016/j.colsurfb.2010.07.046
M3 - Article
C2 - 20846836
AN - SCOPUS:77957666946
SN - 0927-7765
VL - 82
SP - 8
EP - 12
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 1
ER -