Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats

Henya C. Grossman; Maria M. Hadjimarkou; Robert M. Silva; Silvia Q. Giraudo; Richard J. Bodnar

doi:10.1016/S0006-8993(03)03442-5

Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats

Henya C. Grossman, Maria M. Hadjimarkou, Robert M. Silva, Silvia Q. Giraudo, Richard J. Bodnar

Department of Social Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The present study examined the interrelationships between feeding responses produced by μ opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the μ-sensitive opioid peptide, β-endorphin (βEND, 10 μg, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, icv). Moreover, the selective μ opioid antagonist, β-funaltrexamine (βFNA: 2-20 μg, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake.

Original language	English
Pages (from-to)	240-244
Number of pages	5
Journal	Brain Research
Volume	991
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)03442-5
Publication status	Published - 21 Nov 2003

Keywords

β- Funaltrexamine
β-Endorphin
Body weight
Food intake
MTII
SHU-9119

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10.1016/S0006-8993(03)03442-5

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title = "Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats",

abstract = "The present study examined the interrelationships between feeding responses produced by μ opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the μ-sensitive opioid peptide, β-endorphin (βEND, 10 μg, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, icv). Moreover, the selective μ opioid antagonist, β-funaltrexamine (βFNA: 2-20 μg, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake.",

keywords = "β- Funaltrexamine, β-Endorphin, Body weight, Food intake, MTII, SHU-9119",

author = "Grossman, {Henya C.} and Hadjimarkou, {Maria M.} and Silva, {Robert M.} and Giraudo, {Silvia Q.} and Bodnar, {Richard J.}",

year = "2003",

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AU - Grossman, Henya C.

AU - Hadjimarkou, Maria M.

AU - Silva, Robert M.

AU - Giraudo, Silvia Q.

AU - Bodnar, Richard J.

PY - 2003/11/21

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N2 - The present study examined the interrelationships between feeding responses produced by μ opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the μ-sensitive opioid peptide, β-endorphin (βEND, 10 μg, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, icv). Moreover, the selective μ opioid antagonist, β-funaltrexamine (βFNA: 2-20 μg, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake.

AB - The present study examined the interrelationships between feeding responses produced by μ opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the μ-sensitive opioid peptide, β-endorphin (βEND, 10 μg, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, icv). Moreover, the selective μ opioid antagonist, β-funaltrexamine (βFNA: 2-20 μg, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake.

KW - β- Funaltrexamine

KW - β-Endorphin

KW - Body weight

KW - Food intake

KW - MTII

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SP - 240

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JF - Brain Research

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ER -

Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats

Abstract

Keywords

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