Is hypercapnia necessary for the ventilatory response to exercise in man?

K. Murphy, R. P. Stidwill, B. A. Cross, K. D. Leaver, E. Anastassiades, M. Phillips, A. Guz, S. J.G. Semple

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Abstract

Continuous recordings and arterial pH, ventilation, airway CO2 and heart rate were made during rest and during 3-4 min periods of rhythmic leg exercise in four renal patients with arteriovenous shunts. The patients were anaemic (haemoglobin 6.5-9.0 g/dl) but had a normal ventilatory response to exercise as judged by the ratio of the change in ventilation to the change in CO2 production. Breath-by-breath oscillations in arterial pH disappeared for the majority of the exercise period in each patient. Changes in mean arterial pH and end-tidal CO2 tension with exercise were inconsistent between subjects but consistent within a given subject. On average, mean arterial pH rose by 0.011 pH unit. Changes in end-tidal CO2 tension reflected changes in mean pHa by falling on average by 1 mmHg (0.13 kPa). Hypercapnia and acidaemia were not found to be necessary for the ventilatory response to moderate exercise.

Original languageEnglish
Pages (from-to)617-625
Number of pages9
JournalClinical Science
Volume73
Issue number6
Publication statusPublished - 1987

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    Murphy, K., Stidwill, R. P., Cross, B. A., Leaver, K. D., Anastassiades, E., Phillips, M., Guz, A., & Semple, S. J. G. (1987). Is hypercapnia necessary for the ventilatory response to exercise in man? Clinical Science, 73(6), 617-625.