Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

Jeff Linnen, John Wages, Zhen Yong Zhang-Keck, Kirk E. Fry, Krzysztof Z. Krawczynski, Harvey Alter, Eugene Koonin, Margaret Gallagher, Miriam Alter, Stephanos Hadziyannis, Peter Karayiannis, Kevin Fung, Yoshiyuki Nakatsuji, J. Wai Kuo Shin, Lavonne Young, Michael Piatak, Cameron Hoover, John Fernandez, Stacie Chen, Jian Chao ZouTimothy Morris, Kenneth C. Hyams, Susan Ismay, Jeffrey D. Lifson, Georg Hess, Steven K H Foung, Howard Thomas, Daniel Bradley, Harold Margolis, Jungsuh P. Kim

Research output: Contribution to journalArticle

1325 Citations (Scopus)

Abstract

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis, Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalScience
Volume271
Issue number5248
Publication statusPublished - 26 Jan 1996

Fingerprint Dive into the research topics of 'Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent'. Together they form a unique fingerprint.

  • Cite this

    Linnen, J., Wages, J., Zhang-Keck, Z. Y., Fry, K. E., Krawczynski, K. Z., Alter, H., Koonin, E., Gallagher, M., Alter, M., Hadziyannis, S., Karayiannis, P., Fung, K., Nakatsuji, Y., Shin, J. W. K., Young, L., Piatak, M., Hoover, C., Fernandez, J., Chen, S., ... Kim, J. P. (1996). Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent. Science, 271(5248), 505-508.