Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

Jeff Linnen; John Wages; Zhen Yong Zhang-Keck; Kirk E. Fry; Krzysztof Z. Krawczynski; Harvey Alter; Eugene Koonin; Margaret Gallagher; Miriam Alter; Stephanos Hadziyannis; Peter Karayiannis; Kevin Fung; Yoshiyuki Nakatsuji; J. Wai Kuo Shin; Lavonne Young; Michael Piatak; Cameron Hoover; John Fernandez; Stacie Chen; Jian Chao Zou; Timothy Morris; Kenneth C. Hyams; Susan Ismay; Jeffrey D. Lifson; Georg Hess; Steven K H Foung; Howard Thomas; Daniel Bradley; Harold Margolis; Jungsuh P. Kim

Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

Jeff Linnen, John Wages, Zhen Yong Zhang-Keck, Kirk E. Fry, Krzysztof Z. Krawczynski, Harvey Alter, Eugene Koonin, Margaret Gallagher, Miriam Alter, Stephanos Hadziyannis, Peter Karayiannis, Kevin Fung, Yoshiyuki Nakatsuji, J. Wai Kuo Shin, Lavonne Young, Michael Piatak, Cameron Hoover, John Fernandez, Stacie Chen, Jian Chao ZouTimothy Morris, Kenneth C. Hyams, Susan Ismay, Jeffrey D. Lifson, Georg Hess, Steven K H Foung, Howard Thomas, Daniel Bradley, Harold Margolis, Jungsuh P. Kim

Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis, Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

Original language	English
Pages (from-to)	505-508
Number of pages	4
Journal	Science
Volume	271
Issue number	5248
Publication status	Published - 26 Jan 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Linnen, J., Wages, J., Zhang-Keck, Z. Y., Fry, K. E., Krawczynski, K. Z., Alter, H., Koonin, E., Gallagher, M., Alter, M., Hadziyannis, S., Karayiannis, P., Fung, K., Nakatsuji, Y., Shin, J. W. K., Young, L., Piatak, M., Hoover, C., Fernandez, J., Chen, S., ... Kim, J. P. (1996). Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent. Science, 271(5248), 505-508.

@article{523edb3412144565931b57a643d9b52f,

title = "Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent",

abstract = "An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis, Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.",

author = "Jeff Linnen and John Wages and Zhang-Keck, \{Zhen Yong\} and Fry, \{Kirk E.\} and Krawczynski, \{Krzysztof Z.\} and Harvey Alter and Eugene Koonin and Margaret Gallagher and Miriam Alter and Stephanos Hadziyannis and Peter Karayiannis and Kevin Fung and Yoshiyuki Nakatsuji and Shin, \{J. Wai Kuo\} and Lavonne Young and Michael Piatak and Cameron Hoover and John Fernandez and Stacie Chen and Zou, \{Jian Chao\} and Timothy Morris and Hyams, \{Kenneth C.\} and Susan Ismay and Lifson, \{Jeffrey D.\} and Georg Hess and Foung, \{Steven K H\} and Howard Thomas and Daniel Bradley and Harold Margolis and Kim, \{Jungsuh P.\}",

year = "1996",

month = jan,

day = "26",

language = "English",

volume = "271",

pages = "505--508",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5248",

}

Linnen, J, Wages, J, Zhang-Keck, ZY, Fry, KE, Krawczynski, KZ, Alter, H, Koonin, E, Gallagher, M, Alter, M, Hadziyannis, S, Karayiannis, P, Fung, K, Nakatsuji, Y, Shin, JWK, Young, L, Piatak, M, Hoover, C, Fernandez, J, Chen, S, Zou, JC, Morris, T, Hyams, KC, Ismay, S, Lifson, JD, Hess, G, Foung, SKH, Thomas, H, Bradley, D, Margolis, H & Kim, JP 1996, 'Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent', Science, vol. 271, no. 5248, pp. 505-508.

TY - JOUR

T1 - Molecular cloning and disease association of hepatitis G virus

T2 - A transfusion-transmissible agent

AU - Linnen, Jeff

AU - Wages, John

AU - Zhang-Keck, Zhen Yong

AU - Fry, Kirk E.

AU - Krawczynski, Krzysztof Z.

AU - Alter, Harvey

AU - Koonin, Eugene

AU - Gallagher, Margaret

AU - Alter, Miriam

AU - Hadziyannis, Stephanos

AU - Karayiannis, Peter

AU - Fung, Kevin

AU - Nakatsuji, Yoshiyuki

AU - Shin, J. Wai Kuo

AU - Young, Lavonne

AU - Piatak, Michael

AU - Hoover, Cameron

AU - Fernandez, John

AU - Chen, Stacie

AU - Zou, Jian Chao

AU - Morris, Timothy

AU - Hyams, Kenneth C.

AU - Ismay, Susan

AU - Lifson, Jeffrey D.

AU - Hess, Georg

AU - Foung, Steven K H

AU - Thomas, Howard

AU - Bradley, Daniel

AU - Margolis, Harold

AU - Kim, Jungsuh P.

PY - 1996/1/26

Y1 - 1996/1/26

N2 - An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis, Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

AB - An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis, Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

UR - https://www.scopus.com/pages/publications/13244300646

M3 - Article

C2 - 8560265

AN - SCOPUS:13244300646

SN - 0036-8075

VL - 271

SP - 505

EP - 508

JO - Science

JF - Science

IS - 5248

ER -

Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent

Abstract

UN SDGs

Other files and links

Fingerprint

Cite this