Molecular variants of hepatitis B surface antigen (HBsAg)

Seyed Mohammad Jazayeri; Seyed Moayed Alavian; Payam Dindoost; Howard C. Thomas; Peter Karayiannis

doi:10.1002/9781118637272.ch8

Molecular variants of hepatitis B surface antigen (HBsAg)

Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C. Thomas, Peter Karayiannis

Medical School

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The division of hepatitis B virus (HBV) isolated from different geographical regions into genotypes and subtypes has long been recognized. This division is based on amino acid variation in the hepatitis B surface antigen (HBsAg) encoding region and, more specifically, the hydrophilic region that constitutes the a antigenic determinant. This same region constitutes the major neutralizing epitope recognized by natural infection- and vaccine-induced antibodies. However, a number of mutations have been described in different clinical settings that allow the virus to evade the neutralizing immune response. This chapter aims to review the current level of knowledge regarding HBsAg variants.

Original language	English
Title of host publication	Viral Hepatitis
Subtitle of host publication	Fourth Edition
Publisher	wiley
Pages	107-126
Number of pages	20
ISBN (Electronic)	9781118637272
ISBN (Print)	9780470672952
DOIs	https://doi.org/10.1002/9781118637272.ch8
Publication status	Published - 29 Jul 2013

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AU - Dindoost, Payam

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AU - Karayiannis, Peter

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AB - The division of hepatitis B virus (HBV) isolated from different geographical regions into genotypes and subtypes has long been recognized. This division is based on amino acid variation in the hepatitis B surface antigen (HBsAg) encoding region and, more specifically, the hydrophilic region that constitutes the a antigenic determinant. This same region constitutes the major neutralizing epitope recognized by natural infection- and vaccine-induced antibodies. However, a number of mutations have been described in different clinical settings that allow the virus to evade the neutralizing immune response. This chapter aims to review the current level of knowledge regarding HBsAg variants.

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BT - Viral Hepatitis

PB - wiley

ER -

Molecular variants of hepatitis B surface antigen (HBsAg)

Abstract

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