Molecular variants of hepatitis B surface antigen (HBsAg)

Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C. Thomas, Peter Karayiannis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The division of hepatitis B virus (HBV) isolated from different geographical regions into genotypes and subtypes has long been recognized. This division is based on amino acid variation in the hepatitis B surface antigen (HBsAg) encoding region and, more specifically, the hydrophilic region that constitutes the a antigenic determinant. This same region constitutes the major neutralizing epitope recognized by natural infection- and vaccine-induced antibodies. However, a number of mutations have been described in different clinical settings that allow the virus to evade the neutralizing immune response. This chapter aims to review the current level of knowledge regarding HBsAg variants.

Original languageEnglish
Title of host publicationViral Hepatitis
Subtitle of host publicationFourth Edition
Number of pages20
ISBN (Electronic)9781118637272
ISBN (Print)9780470672952
Publication statusPublished - 29 Jul 2013


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