Non-invasive investigation of liver disease in haemophilic patients

Elizabeth J. Miller, Christine A. Lee, P. Karayiannis, S. J. Hamilton-Dutoit, R. Dick, H. C. Thomas, P. B.A. Kernoff

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6 Citations (Scopus)


Liver biopsy specimens previously taken from 16 haemophilic patients with chronic non-A, non-B hepatitis were reviewed. The degree of fibrosis correlated with serum procollagen III peptide (sPIIIP) concentrations, measured both at the time of biopsy and 4-25 years later. Two patients with extremely high sPIIIP concentrations had collateral veins on computed tomography, suggesting portal hypertension. Twenty eight of 47 patients (60%) had splenomegaly on computed tomography, and of 28 patients in whom intravenous contrast medium was used, seven (25%) had collateral oesophageal veins. Serum procollagen III peptide estimations and computed tomography, both non-invasive investigations, indicated that hepatic fibrosis and portal hypertension had developed in a proportion of haemophilic patients with non-A, non-B hepatitis. Infection with the human immunodeficiency virus (HIV) may modify the course of this presumably cytopathic virus infection of the liver.

Original languageEnglish
Pages (from-to)1039-1043
Number of pages5
JournalJournal of Clinical Pathology
Issue number10
Publication statusPublished - 1988


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