TY - JOUR
T1 - Non-invasive investigation of liver disease in haemophilic patients
AU - Miller, Elizabeth J.
AU - Lee, Christine A.
AU - Karayiannis, P.
AU - Hamilton-Dutoit, S. J.
AU - Dick, R.
AU - Thomas, H. C.
AU - Kernoff, P. B.A.
PY - 1988
Y1 - 1988
N2 - Liver biopsy specimens previously taken from 16 haemophilic patients with chronic non-A, non-B hepatitis were reviewed. The degree of fibrosis correlated with serum procollagen III peptide (sPIIIP) concentrations, measured both at the time of biopsy and 4-25 years later. Two patients with extremely high sPIIIP concentrations had collateral veins on computed tomography, suggesting portal hypertension. Twenty eight of 47 patients (60%) had splenomegaly on computed tomography, and of 28 patients in whom intravenous contrast medium was used, seven (25%) had collateral oesophageal veins. Serum procollagen III peptide estimations and computed tomography, both non-invasive investigations, indicated that hepatic fibrosis and portal hypertension had developed in a proportion of haemophilic patients with non-A, non-B hepatitis. Infection with the human immunodeficiency virus (HIV) may modify the course of this presumably cytopathic virus infection of the liver.
AB - Liver biopsy specimens previously taken from 16 haemophilic patients with chronic non-A, non-B hepatitis were reviewed. The degree of fibrosis correlated with serum procollagen III peptide (sPIIIP) concentrations, measured both at the time of biopsy and 4-25 years later. Two patients with extremely high sPIIIP concentrations had collateral veins on computed tomography, suggesting portal hypertension. Twenty eight of 47 patients (60%) had splenomegaly on computed tomography, and of 28 patients in whom intravenous contrast medium was used, seven (25%) had collateral oesophageal veins. Serum procollagen III peptide estimations and computed tomography, both non-invasive investigations, indicated that hepatic fibrosis and portal hypertension had developed in a proportion of haemophilic patients with non-A, non-B hepatitis. Infection with the human immunodeficiency virus (HIV) may modify the course of this presumably cytopathic virus infection of the liver.
UR - http://www.scopus.com/inward/record.url?scp=0023769763&partnerID=8YFLogxK
U2 - 10.1136/jcp.41.10.1039
DO - 10.1136/jcp.41.10.1039
M3 - Article
C2 - 3142933
AN - SCOPUS:0023769763
SN - 0021-9746
VL - 41
SP - 1039
EP - 1043
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 10
ER -