TY - JOUR
T1 - Novel Zinc and Vanadium (V) Hydroquinonate Complexes
T2 - Synthesis and Biological Solution Evaluation
AU - Ioannou, Kyriakos
AU - Eleftheriou, Constantina
AU - Drouza, Chryssoula
AU - Pafiti, Kyriaki S.
AU - Panayi, Tolis
AU - Keramidas, Anastasios D.
AU - Zacharia, Lefteris C.
AU - Vlasiou, Manos C.
N1 - Funding Information:
The authors want to acknowledge Dr. Sophia Hatdjithoma at the Department of Chemistry of the University of Cyprus for the NMR experiments.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/6/5
Y1 - 2022/6/5
N2 - Four novel mononuclear complexes of Zn2+ and V5+ ions were synthesized by the chelation of tridentate ligands of hydroquinone derivatives in 1:1 M ratios. The synthesis of the two novel ligands and their metal complexes were identified and characterized by NMR, IR, UV–Vis, cyclic voltammetry, and conductivity measurements. Structural information was also collected using computational chemistry and density functional theory studies. The biological activity of these metal complexes was investigated by the ctDNA interaction process via UV–Vis and viscosity measurements. The synthesized compounds C1 – C4 were primarily screened for their in vitro anti-microbial activities against gram-positive, gram-negative bacteria, and their anticancer potential against MDA-MB-231 cells carried out by MTT assay. Furthermore, on the complex molecules, we performed DPPH antioxidant studies and BSA (bovine serum albumin) binding studies on the UV–Vis. Additionally, studies were performed in silico by molecular docking evaluation of the molecules against breast cancer-related proteins. The data show that complexes C1- C4, have anticancer activity even in cells that showed resistivity against cis-platin (C3 > C4 > C2, C1) and the complexes (C2 > C1), have antibacterial activity against gram-positive bacteria. Another remarkable piece of evidence is that the anticancer activity of the molecules does not occur only because of their prooxidant activity, since C4 compound resulted in antioxidant activity.
AB - Four novel mononuclear complexes of Zn2+ and V5+ ions were synthesized by the chelation of tridentate ligands of hydroquinone derivatives in 1:1 M ratios. The synthesis of the two novel ligands and their metal complexes were identified and characterized by NMR, IR, UV–Vis, cyclic voltammetry, and conductivity measurements. Structural information was also collected using computational chemistry and density functional theory studies. The biological activity of these metal complexes was investigated by the ctDNA interaction process via UV–Vis and viscosity measurements. The synthesized compounds C1 – C4 were primarily screened for their in vitro anti-microbial activities against gram-positive, gram-negative bacteria, and their anticancer potential against MDA-MB-231 cells carried out by MTT assay. Furthermore, on the complex molecules, we performed DPPH antioxidant studies and BSA (bovine serum albumin) binding studies on the UV–Vis. Additionally, studies were performed in silico by molecular docking evaluation of the molecules against breast cancer-related proteins. The data show that complexes C1- C4, have anticancer activity even in cells that showed resistivity against cis-platin (C3 > C4 > C2, C1) and the complexes (C2 > C1), have antibacterial activity against gram-positive bacteria. Another remarkable piece of evidence is that the anticancer activity of the molecules does not occur only because of their prooxidant activity, since C4 compound resulted in antioxidant activity.
KW - Antibacterial
KW - Anticancer
KW - Metal complexes
KW - Synthesis
KW - Vanadium
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=85124454322&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2022.132582
DO - 10.1016/j.molstruc.2022.132582
M3 - Article
AN - SCOPUS:85124454322
SN - 0022-2860
VL - 1257
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
M1 - 132582
ER -