TY - JOUR
T1 - Partial ordering of undesirable effects reported for traditionally used medicinal herbal substances
AU - Laina, Danae
AU - Bariotakis, Michael
AU - Lionis, Christos
AU - Castanas, Elias
AU - Brüggemann, Rainer
AU - Pirintsos, Stergios A.
PY - 2017/9/14
Y1 - 2017/9/14
N2 - According to the World Health Organization, the safety of herbal medicines has become a major concern to both national health authorities and the general public. Here, using partial order analysis, we explore the reported undesirable effects of medicinal herbal substances, in their traditional/ethnopharmacological use. Data were retrieved from the European Union list of herbal substances for use in traditional medicinal products and the final European Union herbal monographs of the European Medicines Agency. Our analysis revealed that the attributes (reported to undesirable effects) of the poset with the highest sensitivity were (in diminishing order) the gastrointestinal disorders, allergic skin reactions, allergic reactions and hypersensitivity reactions. Variation in undesirable effects of herbal substances between major phylogenetic groups of origin plants was also recorded and an overall arrangement of medicinal herbal substances in a rank order was achieved. This classification may serve as a guide for decision-making process for both healthcare providers and consumers.
AB - According to the World Health Organization, the safety of herbal medicines has become a major concern to both national health authorities and the general public. Here, using partial order analysis, we explore the reported undesirable effects of medicinal herbal substances, in their traditional/ethnopharmacological use. Data were retrieved from the European Union list of herbal substances for use in traditional medicinal products and the final European Union herbal monographs of the European Medicines Agency. Our analysis revealed that the attributes (reported to undesirable effects) of the poset with the highest sensitivity were (in diminishing order) the gastrointestinal disorders, allergic skin reactions, allergic reactions and hypersensitivity reactions. Variation in undesirable effects of herbal substances between major phylogenetic groups of origin plants was also recorded and an overall arrangement of medicinal herbal substances in a rank order was achieved. This classification may serve as a guide for decision-making process for both healthcare providers and consumers.
KW - Asterids–Rosids, partial order
KW - herbal substances
KW - medicinal use
KW - Pharmacognosy
KW - traditional medicine
KW - undesirable effects
UR - http://www.scopus.com/inward/record.url?scp=85018494635&partnerID=8YFLogxK
U2 - 10.1080/02772248.2017.1294692
DO - 10.1080/02772248.2017.1294692
M3 - Article
AN - SCOPUS:85018494635
SN - 0277-2248
VL - 99
SP - 1230
EP - 1241
JO - Toxicological and Environmental Chemistry
JF - Toxicological and Environmental Chemistry
IS - 7-8
ER -