Peptidomimetic-functionalized carbon nanotubes with antitrypsin activity

Nikolaos Karousis, Rigini M. Papi, Argiris Siskos, Paraskevi Vakalopoulou, Petros Glezakos, Yiannis Sarigiannis, Georgios Stavropoulos, Dimitrios A. Kyriakidis, Nikos Tagmatarchis

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11 Citations (Scopus)

Abstract

Water-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics. The structural design of the covalently grafted peptidomimetics to the CNTs is based on their structural similarity with the metabolites of antagonist G of substance P. A variety of analytical spectroscopic methods, in combination with electron microscopy and thermal analysis, aided the structural and morphological characterization of the four newly synthesized peptidomimetic-CNT conjugates. It is demonstrated that the trypsin inhibitory effect of the peptidomimetic-CNT is enhanced as a result of the high-loading of peptidomimetics onto the skeleton of the modified water-soluble CNTs. Additionally, the peptidomimetic-functionalized CNT conjugates can be recovered and re-employed up to six biological evaluation cycles showing the same trypsin inhibitory activity. Such a nanosized system is extremely advantageous for the inhibition of inflammation or malignancy and could find potential future biological applications in the area of drug delivery systems.

Original languageEnglish
Pages (from-to)3550-3558
Number of pages9
JournalCarbon
Volume47
Issue number15
DOIs
Publication statusPublished - Dec 2009

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    Karousis, N., Papi, R. M., Siskos, A., Vakalopoulou, P., Glezakos, P., Sarigiannis, Y., Stavropoulos, G., Kyriakidis, D. A., & Tagmatarchis, N. (2009). Peptidomimetic-functionalized carbon nanotubes with antitrypsin activity. Carbon, 47(15), 3550-3558. https://doi.org/10.1016/j.carbon.2009.08.025