Perinatal and parental risk factors in an epidemiological study of children with autism spectrum disorder

Dimitrios C. Cassimos, Christine K. Syriopoulou-Delli, Grigorios I. Tripsianis, Ioannis Tsikoulas

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study examines several perinatal and parental risk factors in an epidemiological study of children with autism spectrum disorders (ASD). Methods: Based on a sample of 273 children with ASD who have been followed up at a General Hospital of North Greece, an additional sample of 273 healthy children, matched for age, is also recruited as a control group. Results: The innovative results indicate significant correlation of ASD with three critical categories of factors: genetic, perinatal, and environmental. According to the empirical findings of multivariate logistic regression analysis, critical factors indicating higher risk for autism disorders include: male gender; gestational age (GA); multiple gestations; maternal age at delivery; and, maternal education. Conclusions: The significant impact of perinatal and environmental factors can be indicative of their amplifying impact on genetic prone subjects.

Original languageEnglish
Pages (from-to)108-116
Number of pages9
JournalInternational Journal of Developmental Disabilities
Volume62
Issue number2
DOIs
Publication statusPublished - 2016

Keywords

  • Autism
  • Environmental
  • Genetic
  • Perinatal
  • Risk factors

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