TY - JOUR
T1 - Perinatal and parental risk factors in an epidemiological study of children with autism spectrum disorder
AU - Cassimos, Dimitrios C.
AU - Syriopoulou-Delli, Christine K.
AU - Tripsianis, Grigorios I.
AU - Tsikoulas, Ioannis
PY - 2016
Y1 - 2016
N2 - Objectives: This study examines several perinatal and parental risk factors in an epidemiological study of children with autism spectrum disorders (ASD). Methods: Based on a sample of 273 children with ASD who have been followed up at a General Hospital of North Greece, an additional sample of 273 healthy children, matched for age, is also recruited as a control group. Results: The innovative results indicate significant correlation of ASD with three critical categories of factors: genetic, perinatal, and environmental. According to the empirical findings of multivariate logistic regression analysis, critical factors indicating higher risk for autism disorders include: male gender; gestational age (GA); multiple gestations; maternal age at delivery; and, maternal education. Conclusions: The significant impact of perinatal and environmental factors can be indicative of their amplifying impact on genetic prone subjects.
AB - Objectives: This study examines several perinatal and parental risk factors in an epidemiological study of children with autism spectrum disorders (ASD). Methods: Based on a sample of 273 children with ASD who have been followed up at a General Hospital of North Greece, an additional sample of 273 healthy children, matched for age, is also recruited as a control group. Results: The innovative results indicate significant correlation of ASD with three critical categories of factors: genetic, perinatal, and environmental. According to the empirical findings of multivariate logistic regression analysis, critical factors indicating higher risk for autism disorders include: male gender; gestational age (GA); multiple gestations; maternal age at delivery; and, maternal education. Conclusions: The significant impact of perinatal and environmental factors can be indicative of their amplifying impact on genetic prone subjects.
KW - Autism
KW - Environmental
KW - Genetic
KW - Perinatal
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84962633307&partnerID=8YFLogxK
U2 - 10.1179/2047387715Y.0000000004
DO - 10.1179/2047387715Y.0000000004
M3 - Article
AN - SCOPUS:84962633307
SN - 2047-3869
VL - 62
SP - 108
EP - 116
JO - International Journal of Developmental Disabilities
JF - International Journal of Developmental Disabilities
IS - 2
ER -