Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight

C. Pantos; I. Mourouzis; I. Paizis; V. Malliopoulou; Ch Xinaris; P. Moraitis; A. D. Cokkinos; D. V. Cokkinos

doi:10.1111/j.1463-1326.2006.00587.x

Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight

C. Pantos, I. Mourouzis, I. Paizis, V. Malliopoulou, Ch Xinaris, P. Moraitis, A. D. Cokkinos, D. V. Cokkinos

Research output: Contribution to journal › Article › peer-review

Abstract

It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.

Original language	English
Pages (from-to)	136-138
Number of pages	3
Journal	Diabetes, Obesity and Metabolism
Volume	9
Issue number	1
DOIs	https://doi.org/10.1111/j.1463-1326.2006.00587.x
Publication status	Published - Jan 2007
Externally published	Yes

Keywords

Body weight
Obesity
Rats
Thyroid analogs
Thyroxine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1463-1326.2006.00587.x

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Pantos, C., Mourouzis, I., Paizis, I., Malliopoulou, V., Xinaris, C., Moraitis, P., Cokkinos, A. D., & Cokkinos, D. V. (2007). Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight. Diabetes, Obesity and Metabolism, 9(1), 136-138. https://doi.org/10.1111/j.1463-1326.2006.00587.x

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title = "Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight",

abstract = "It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.",

keywords = "Body weight, Obesity, Rats, Thyroid analogs, Thyroxine",

author = "C. Pantos and I. Mourouzis and I. Paizis and V. Malliopoulou and Ch Xinaris and P. Moraitis and Cokkinos, \{A. D.\} and Cokkinos, \{D. V.\}",

year = "2007",

month = jan,

doi = "10.1111/j.1463-1326.2006.00587.x",

language = "English",

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Pantos, C, Mourouzis, I, Paizis, I, Malliopoulou, V, Xinaris, C, Moraitis, P, Cokkinos, AD & Cokkinos, DV 2007, 'Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight', Diabetes, Obesity and Metabolism, vol. 9, no. 1, pp. 136-138. https://doi.org/10.1111/j.1463-1326.2006.00587.x

TY - JOUR

T1 - Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats

T2 - Potential therapeutic implications in controlling body weight

AU - Pantos, C.

AU - Mourouzis, I.

AU - Paizis, I.

AU - Malliopoulou, V.

AU - Xinaris, Ch

AU - Moraitis, P.

AU - Cokkinos, A. D.

AU - Cokkinos, D. V.

PY - 2007/1

Y1 - 2007/1

N2 - It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.

AB - It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.

KW - Body weight

KW - Obesity

KW - Rats

KW - Thyroid analogs

KW - Thyroxine

UR - https://www.scopus.com/pages/publications/33845533411

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DO - 10.1111/j.1463-1326.2006.00587.x

M3 - Article

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AN - SCOPUS:33845533411

SN - 1462-8902

VL - 9

SP - 136

EP - 138

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 1

ER -

Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: Potential therapeutic implications in controlling body weight

Abstract

Keywords

UN SDGs

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