Platelet alpha2-adrenergic receptor function in psychiatric disorders

Philip D. Kanof; Celeste A. Johns; Michael Davidson; Larry J. Siever; Emil F. Coccaro; Kenneth L. Davis

doi:10.1016/0165-1781(88)90030-3

Platelet alpha₂-adrenergic receptor function in psychiatric disorders

Philip D. Kanof
, Celeste A. Johns
, Michael Davidson
, Larry J. Siever
, Emil F. Coccaro
, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

Abstract

The inhibitory effects of norepinephrine (NE) on the cyclic adenosine-3′,5′-monophosphate (cAMP) response to prostaglandin E₁ (PGE₁), a measure of α₂-adrenergic receptor function, have been compared in platelets from drug-free schizophrenic patients, depressive patients, and normal controls. The absolute value of the inhibition by NE of the cAMP response to PGE₁ was smaller in platelets from schizophrenic and depressive patients than in controls. However, this result was secondary to the smaller baseline platelet cAMP response to PGE₁ in patients with these disorders. Effects of NE on cAMP production did not discriminate between actively ill and remitted patients with either schizophrenia or depression. Platelet α₂-receptor sensitivity, as measured by the effects of NE on cAMP production, does not appear to be altered in these psychiatric disorders.

Original language	English
Pages (from-to)	11-22
Number of pages	12
Journal	Psychiatry Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(88)90030-3
Publication status	Published - Jan 1988
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

depression
platelet
Schizophrenia
α-receptor sensitivity

Access to Document

10.1016/0165-1781(88)90030-3

Cite this

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title = "Platelet alpha2-adrenergic receptor function in psychiatric disorders",

abstract = "The inhibitory effects of norepinephrine (NE) on the cyclic adenosine-3′,5′-monophosphate (cAMP) response to prostaglandin E1 (PGE1), a measure of α2-adrenergic receptor function, have been compared in platelets from drug-free schizophrenic patients, depressive patients, and normal controls. The absolute value of the inhibition by NE of the cAMP response to PGE1 was smaller in platelets from schizophrenic and depressive patients than in controls. However, this result was secondary to the smaller baseline platelet cAMP response to PGE1 in patients with these disorders. Effects of NE on cAMP production did not discriminate between actively ill and remitted patients with either schizophrenia or depression. Platelet α2-receptor sensitivity, as measured by the effects of NE on cAMP production, does not appear to be altered in these psychiatric disorders.",

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AU - Kanof, Philip D.

AU - Johns, Celeste A.

AU - Davidson, Michael

AU - Siever, Larry J.

AU - Coccaro, Emil F.

AU - Davis, Kenneth L.

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AB - The inhibitory effects of norepinephrine (NE) on the cyclic adenosine-3′,5′-monophosphate (cAMP) response to prostaglandin E1 (PGE1), a measure of α2-adrenergic receptor function, have been compared in platelets from drug-free schizophrenic patients, depressive patients, and normal controls. The absolute value of the inhibition by NE of the cAMP response to PGE1 was smaller in platelets from schizophrenic and depressive patients than in controls. However, this result was secondary to the smaller baseline platelet cAMP response to PGE1 in patients with these disorders. Effects of NE on cAMP production did not discriminate between actively ill and remitted patients with either schizophrenia or depression. Platelet α2-receptor sensitivity, as measured by the effects of NE on cAMP production, does not appear to be altered in these psychiatric disorders.

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