Platelet-derived growth factor (PDGF): Actions and mechanisms in vascular smooth muscle

A. D. Hughes, G. F. Clunn, J. Refson, C. Demoliou-Mason

Research output: Contribution to journalReview article

116 Citations (Scopus)

Abstract

PDGF is a highly hydrophilic cationic glycoprotein (Mr 28-35 kDa) produced by platelets, monocyte/macrophages, endothelial cells and vascular smooth muscle cells under some conditions. Since its original description, PDGF has attracted much attention and it is currently believed to play a role in atherosclerosis and other vascular pathologies. This review describes the vascular biology of PDGF. It particularly focuses on recent findings regarding the intracellular signals activated by PDGF in the context of vascular smooth muscle cell proliferation, migration and contraction.

Original languageEnglish
Pages (from-to)1079-1089
Number of pages11
JournalGeneral Pharmacology
Volume27
Issue number7
DOIs
Publication statusPublished - Oct 1996

Keywords

  • chemotaxis
  • excitation-contraction coupling
  • migration
  • pathophysiology
  • platelet-derived growth factor
  • proliferation
  • signal transduction
  • vascular smooth muscle cell

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