Platelet phospholipid synthesis in Alzheimer's disease

Philip D. Kanof; Richard C. Mohs; Joel Gross; Michael Davidson; Linda M. Bierer; Kenneth L. Davis

doi:10.1016/0197-4580(91)90041-H

Platelet phospholipid synthesis in Alzheimer's disease

Philip D. Kanof
, Richard C. Mohs
, Joel Gross
, Michael Davidson
, Linda M. Bierer
, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

Abstract

The rates of incorporation of [³H]choline and [³H]ethanolamine into membrane phospholipids of platelets from 22 drug-free Alzheimer's disease patients and 18 normal elderly controls were compared. No significant differences between groups were found. If alterations in lipid metabolism are involved in the pathophysiological processes underlying Alzheimer's disease, such alterations are not manifest in measures of radiolabeled base incorporation into platelet phospholipids.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Neurobiology of Aging
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0197-4580(91)90041-H
Publication status	Published - 1991
Externally published	Yes

Keywords

Alzheimer's disease
Choline
Ethanolamine
Phospholipids
Platelets

Access to Document

10.1016/0197-4580(91)90041-H

Cite this

@article{a3d7ca443c044dada2c38e424a32c64a,

title = "Platelet phospholipid synthesis in Alzheimer's disease",

abstract = "The rates of incorporation of [3H]choline and [3H]ethanolamine into membrane phospholipids of platelets from 22 drug-free Alzheimer's disease patients and 18 normal elderly controls were compared. No significant differences between groups were found. If alterations in lipid metabolism are involved in the pathophysiological processes underlying Alzheimer's disease, such alterations are not manifest in measures of radiolabeled base incorporation into platelet phospholipids.",

keywords = "Alzheimer's disease, Choline, Ethanolamine, Phospholipids, Platelets",

author = "Kanof, \{Philip D.\} and Mohs, \{Richard C.\} and Joel Gross and Michael Davidson and Bierer, \{Linda M.\} and Davis, \{Kenneth L.\}",

year = "1991",

doi = "10.1016/0197-4580(91)90041-H",

language = "English",

volume = "12",

pages = "65--69",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Platelet phospholipid synthesis in Alzheimer's disease

AU - Kanof, Philip D.

AU - Mohs, Richard C.

AU - Gross, Joel

AU - Davidson, Michael

AU - Bierer, Linda M.

AU - Davis, Kenneth L.

PY - 1991

Y1 - 1991

N2 - The rates of incorporation of [3H]choline and [3H]ethanolamine into membrane phospholipids of platelets from 22 drug-free Alzheimer's disease patients and 18 normal elderly controls were compared. No significant differences between groups were found. If alterations in lipid metabolism are involved in the pathophysiological processes underlying Alzheimer's disease, such alterations are not manifest in measures of radiolabeled base incorporation into platelet phospholipids.

AB - The rates of incorporation of [3H]choline and [3H]ethanolamine into membrane phospholipids of platelets from 22 drug-free Alzheimer's disease patients and 18 normal elderly controls were compared. No significant differences between groups were found. If alterations in lipid metabolism are involved in the pathophysiological processes underlying Alzheimer's disease, such alterations are not manifest in measures of radiolabeled base incorporation into platelet phospholipids.

KW - Alzheimer's disease

KW - Choline

KW - Ethanolamine

KW - Phospholipids

KW - Platelets

UR - https://www.scopus.com/pages/publications/0026032908

U2 - 10.1016/0197-4580(91)90041-H

DO - 10.1016/0197-4580(91)90041-H

M3 - Article

C2 - 2002885

AN - SCOPUS:0026032908

SN - 0197-4580

VL - 12

SP - 65

EP - 69

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 1

ER -

Platelet phospholipid synthesis in Alzheimer's disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this