Pre‐S proteins in hepatitis b

Leo Kuijpers; Marjolijn Koens; Iain Murray‐Lyon; Jon C. Coleman; Peter Karayiannis; Howard C. Thomas; Alessandro Zanetti; A. Cargnel; Tim J. Harrison; Arie J. Zuckerman

doi:10.1002/jmv.1890280111

Pre‐S proteins in hepatitis b

Leo Kuijpers, Marjolijn Koens, Iain Murray‐Lyon, Jon C. Coleman, Peter Karayiannis, Howard C. Thomas, Alessandro Zanetti, A. Cargnel, Tim J. Harrison, Arie J. Zuckerman

Medical School

Research output: Contribution to journal › Editorial › peer-review

Abstract

Two reactive sequences of the pre‐S regions of hepatitis B surface antigen were synthesized chemically and used in micro‐ELISAs for the assay of pre‐S1 and pre‐S2 antigens in serum from patients with acute and chronic hepatitis B. Pre‐S1 antigen correlated well with the presence of HBV‐DNA and was no longer detectable on cessation of viral replication, after natural recovery and after successful treatment with alpha‐interferon. Pre‐S2 proteins were also lost after treatment with alpha‐interferon. The results show that the assay of pre‐S1 and pre‐S2 proteins in serum provides additional useful markers for assessing patients with acute and chronic hepatitis B infection and for monitoring the response to treatment with interferon.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Journal of Medical Virology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1002/jmv.1890280111
Publication status	Published - 1989

Keywords

chemical synthesis
pre‐S antigens
response to alpha‐interferon
viral replication

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10.1002/jmv.1890280111

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title = "Pre‐S proteins in hepatitis b",

abstract = "Two reactive sequences of the pre‐S regions of hepatitis B surface antigen were synthesized chemically and used in micro‐ELISAs for the assay of pre‐S1 and pre‐S2 antigens in serum from patients with acute and chronic hepatitis B. Pre‐S1 antigen correlated well with the presence of HBV‐DNA and was no longer detectable on cessation of viral replication, after natural recovery and after successful treatment with alpha‐interferon. Pre‐S2 proteins were also lost after treatment with alpha‐interferon. The results show that the assay of pre‐S1 and pre‐S2 proteins in serum provides additional useful markers for assessing patients with acute and chronic hepatitis B infection and for monitoring the response to treatment with interferon.",

keywords = "chemical synthesis, pre‐S antigens, response to alpha‐interferon, viral replication",

author = "Leo Kuijpers and Marjolijn Koens and Iain Murray‐Lyon and Coleman, {Jon C.} and Peter Karayiannis and Thomas, {Howard C.} and Alessandro Zanetti and A. Cargnel and Harrison, {Tim J.} and Zuckerman, {Arie J.}",

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doi = "10.1002/jmv.1890280111",

language = "English",

volume = "28",

pages = "47--51",

journal = "Journal of Medical Virology",

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TY - JOUR

T1 - Pre‐S proteins in hepatitis b

AU - Kuijpers, Leo

AU - Koens, Marjolijn

AU - Murray‐Lyon, Iain

AU - Coleman, Jon C.

AU - Karayiannis, Peter

AU - Thomas, Howard C.

AU - Zanetti, Alessandro

AU - Cargnel, A.

AU - Harrison, Tim J.

AU - Zuckerman, Arie J.

PY - 1989

Y1 - 1989

N2 - Two reactive sequences of the pre‐S regions of hepatitis B surface antigen were synthesized chemically and used in micro‐ELISAs for the assay of pre‐S1 and pre‐S2 antigens in serum from patients with acute and chronic hepatitis B. Pre‐S1 antigen correlated well with the presence of HBV‐DNA and was no longer detectable on cessation of viral replication, after natural recovery and after successful treatment with alpha‐interferon. Pre‐S2 proteins were also lost after treatment with alpha‐interferon. The results show that the assay of pre‐S1 and pre‐S2 proteins in serum provides additional useful markers for assessing patients with acute and chronic hepatitis B infection and for monitoring the response to treatment with interferon.

AB - Two reactive sequences of the pre‐S regions of hepatitis B surface antigen were synthesized chemically and used in micro‐ELISAs for the assay of pre‐S1 and pre‐S2 antigens in serum from patients with acute and chronic hepatitis B. Pre‐S1 antigen correlated well with the presence of HBV‐DNA and was no longer detectable on cessation of viral replication, after natural recovery and after successful treatment with alpha‐interferon. Pre‐S2 proteins were also lost after treatment with alpha‐interferon. The results show that the assay of pre‐S1 and pre‐S2 proteins in serum provides additional useful markers for assessing patients with acute and chronic hepatitis B infection and for monitoring the response to treatment with interferon.

KW - chemical synthesis

KW - pre‐S antigens

KW - response to alpha‐interferon

KW - viral replication

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U2 - 10.1002/jmv.1890280111

DO - 10.1002/jmv.1890280111

M3 - Editorial

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AN - SCOPUS:0024474625

SN - 0146-6615

VL - 28

SP - 47

EP - 51

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 1

ER -

Pre‐S proteins in hepatitis b

Abstract

Keywords

UN SDGs

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