TY - JOUR
T1 - Prevalence, Deaths, and Disability-Adjusted Life-Years Due to Asthma and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019
AU - Safiri, Saeid
AU - Carson-Chahhoud, Kristin
AU - Karamzad, Nahid
AU - Sullman, Mark J.M.
AU - Nejadghaderi, Seyed Aria
AU - Taghizadieh, Ali
AU - Bell, Arielle Wilder
AU - Kolahi, Ali Asghar
AU - Ansarin, Khalil
AU - Mansournia, Mohammad Ali
AU - Collins, Gary S.
AU - Kaufman, Jay S.
N1 - Funding Information:
FUNDING/SUPPORT: The Bill and Melinda Gates Foundation, who were not involved in any way in the preparation of this manuscript, funded the Global Burden of Disease study. The Tabriz University of Medical Sciences, Tabriz, Iran [Grant 63734] also supported the present article.Author contributions: S. S. A. T. and K. A. designed the study. S. S. and M. A. M. analyzed the data and performed the statistical analyses. K. C.-C. N. K. M. J. M. S. S. A. N. A. W. B. A.-A. K. K. A. G. S. C. and J. S. K. drafted the initial manuscript. All authors reviewed the drafted the manuscript for critical content. All authors approved the final version of the manuscript. Financial/nonfinancial disclosures: None declared. Other contributions: The authors thank the Institute for Health Metrics and Evaluation staff and its collaborators, who prepared these publicly available data. The authors also like to acknowledge the support of the Tuberculosis and Lung Disease Research Center at the Tabriz University of Medical Sciences, Tabriz, Iran. Ethics approval: The present report was approved by ethics committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1400.230). Additional information: The e-Appendix, e-Figures, and e-Tables can be found in the Supplemental Materials section of the online article.
Funding Information:
Other contributions: The authors thank the Institute for Health Metrics and Evaluation staff and its collaborators, who prepared these publicly available data. The authors also like to acknowledge the support of the Tuberculosis and Lung Disease Research Center at the Tabriz University of Medical Sciences, Tabriz, Iran.
Publisher Copyright:
© 2021 American College of Chest Physicians
PY - 2022/2
Y1 - 2022/2
N2 - Background: Understanding global trends in the point prevalence, deaths, and disability-adjusted life-years (DALYs) for asthma will facilitate evidence-based decision-making. Research Question: What are the global, regional, and national burdens of asthma in 204 countries and territories between 1990 and 2019 by age, sex, and sociodemographic index (SDI)? Study Design and Methods: Publicly available data from the Global Burden of Disease study from 1990 through 2019 were used. All estimates were presented as counts and age-standardized rates per 100,000, along with their associated uncertainty intervals. Results: In 2019, the global age-standardized point prevalence and death rates for asthma were 3,415.5 and 5.8 per 100,000, which represent a 24% and 51.3% decrease since 1990, respectively. Moreover, in 2019, the global age-standardized DALY rate was 273.6 and the global point prevalence of asthma was highest in the group 5 to 9 years of age. Also in 2019, the United States (10,399.3) showed the highest age-standardized point prevalence rate of asthma. Generally, the burden of asthma decreased with increasing SDI. Globally, high BMI (16.9%), smoking (9.9%), and occupational asthmagens (8.8%) contributed to the 2019 asthma DALYs. Interpretation: Asthma remains an important public health issue, particularly in regions with low socioeconomic development. Future research is needed to examine thoroughly the associations asthma has with its risk factors and the factors impeding optimal self-management. Further research also is needed to understand and implement better the interventions that have reduced the burden of asthma.
AB - Background: Understanding global trends in the point prevalence, deaths, and disability-adjusted life-years (DALYs) for asthma will facilitate evidence-based decision-making. Research Question: What are the global, regional, and national burdens of asthma in 204 countries and territories between 1990 and 2019 by age, sex, and sociodemographic index (SDI)? Study Design and Methods: Publicly available data from the Global Burden of Disease study from 1990 through 2019 were used. All estimates were presented as counts and age-standardized rates per 100,000, along with their associated uncertainty intervals. Results: In 2019, the global age-standardized point prevalence and death rates for asthma were 3,415.5 and 5.8 per 100,000, which represent a 24% and 51.3% decrease since 1990, respectively. Moreover, in 2019, the global age-standardized DALY rate was 273.6 and the global point prevalence of asthma was highest in the group 5 to 9 years of age. Also in 2019, the United States (10,399.3) showed the highest age-standardized point prevalence rate of asthma. Generally, the burden of asthma decreased with increasing SDI. Globally, high BMI (16.9%), smoking (9.9%), and occupational asthmagens (8.8%) contributed to the 2019 asthma DALYs. Interpretation: Asthma remains an important public health issue, particularly in regions with low socioeconomic development. Future research is needed to examine thoroughly the associations asthma has with its risk factors and the factors impeding optimal self-management. Further research also is needed to understand and implement better the interventions that have reduced the burden of asthma.
KW - asthma
KW - burden
KW - epidemiology
KW - global
KW - mortality
KW - prevalence
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85123702245&partnerID=8YFLogxK
U2 - 10.1016/j.chest.2021.09.042
DO - 10.1016/j.chest.2021.09.042
M3 - Article
C2 - 34699773
AN - SCOPUS:85123702245
SN - 0012-3692
VL - 161
SP - 318
EP - 329
JO - Chest
JF - Chest
IS - 2
ER -
