Prosthetic venous valves: Short history and advancements from 2012 to 2020.

Constantinos Zervides, Habib Mahdi, Ravit Atara Staub, Hassan Jouni

Research output: Contribution to journalReview articlepeer-review


Chronic Venous Disease is estimated at 83.6% of the global population. Patients experience pain, discomfort and severe complications with few effective therapies being available. Current strategies for the treatment of malfunctioning venous valves are invasive with a high recurrence rate. A prosthetic venous valve replacement is imminent, possibly providing better outcomes and improved general quality of life. In this review, prosthetic venous valves history is presented and assesses the advantages and disadvantages of developed venous valves. Articles that discussed potential designs of prosthetic venous valves were examined. A systematic search produced thirty-five papers fitting the inclusion criteria. Our understanding of the ideal abilities required in prosthetic valves has evolved. Developed valves are reported for regurgitation, migration and leakage. Issues have been resolved, but we are still away from the ideal valve. Improvements within the last eight years provided information on the importance of sinuses and prosthetic to venous wall-size mismatch.

Original languageEnglish
Publication statusAccepted/In press - 2020
Externally publishedYes


  • catheter-based interventions
  • chronic venous disease
  • chronic venous insufficiency
  • endovascular treatment
  • venous reflux


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