Protracted alanine aminotransferase levels in tamarins infected with hepatitis A virus

P. Karayiannis, R. Chitranukroh, M. Fry, L. M. Petrovic, D. Moore, P. J. Scheuer, H. C. Thomas

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Eighteen red‐bellied tamarins (Saguinus labiatus), experimentally infected with hepatitis A virus (HAV), were followed for up to 1.5 years after initial challenge. Half of these animals developed protracted alanine aminotransferase (ALT) abnormalities, which lasted for between 23 and 55 weeks post‐challenge. IgM anti‐HAV was detected intermittently during the early phase of their relapsing hepatitis and never after return of ALT levels to normal. The possibility that these findings may be related to continued HAV replication, coinfection with another agent, or the result of an autoimmune phenomenon triggered by HAV are discussed.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalJournal of Medical Virology
Volume30
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • ALT
  • IgM anti‐HAV

Fingerprint Dive into the research topics of 'Protracted alanine aminotransferase levels in tamarins infected with hepatitis A virus'. Together they form a unique fingerprint.

  • Cite this

    Karayiannis, P., Chitranukroh, R., Fry, M., Petrovic, L. M., Moore, D., Scheuer, P. J., & Thomas, H. C. (1990). Protracted alanine aminotransferase levels in tamarins infected with hepatitis A virus. Journal of Medical Virology, 30(2), 151-158. https://doi.org/10.1002/jmv.1890300214