PTTG-1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy

Alexandros Iliadis, Maria Aikaterini Virvili, Nicolaos A. Flaris, Stavroula Pervana, Elissabet Pazarli, Grigoris Tripsianis, Maria E. Grigoriou, Ioannis Efstratiou, Dimitrios N. Kanakis

Research output: Contribution to journalArticlepeer-review

Abstract

This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade-I, 23 Grade-II and 7 Grade-III meningiomas. Mitotic index (MI), Ki-67/MiB-1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades. In comparison, PTTG expression was on a par with the other two indices, and performed very well regarding identification of advanced grade tumors. PTTG may be considered an important diagnostic tool and serve in the future as a novel prognosticator of the biological behavior of all grade meningiomas as well as a useful high-risk patient selection tool.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalAPMIS
Volume126
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Ki-67
  • meningioma
  • mitotic index
  • Pituitary tumor transforming gene
  • WHO grade

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