Randomised controlled trial of methyldopa and isradipine in preeclampsia - Effects on uteroplacental and fetal hemodynamics

Sven Montan, Chinnaiya Anandakumar, Sabaratnam Arulkumaran, Ingemar Ingemarsson, Shan S. Ratnam

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This is a prospective randomised controlled study in 21 women admitted with preeclampsia in the third trimester. The mean arterial blood pressure decreased by 11.1 mmHg (95% confidence interval -14.9 to -7.3 mmHg) in the methyldopa group, and by 9.3 mmHg (95% confidence interval -14.4 to -4.2 mmHg) in the isradipine group. The maternal heart rate decreased by 6.9 beats per min (95% confidence interval -11.6 to -2.2 bpm) during methyldopa treatment, and by 2.5 beats per min (95% confidence interval -9.2 to 4.3) during isradipine treatment. Pulsatility index in maternal and fetal vessels was not affected by either of the two drugs. The birth weight and placental weight and neonatal outcome were similar and uneventful. The hypotensive effect was similar for methyldopa and isradipine. Except reduced maternal heart rate on methyldopa, fetal and uteroplacental hemodynamics were not altered during treatment of preeclampsia with methyldopa or isradipine.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalJournal of Perinatal Medicine
Volume24
Issue number2
Publication statusPublished - 1996

Keywords

  • Doppler ultrasound
  • Fetal heart
  • Hypertension
  • Isradipine
  • Methyldopa

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