TY - JOUR
T1 - Reintroduction of cow's milk in milk-allergic children
T2 - Safety and risk factors
AU - Vassilopoulou, Emilia
AU - Konstantinou, George
AU - Kassimos, Dimitrios
AU - Douladiris, Nikolaos
AU - Xepapadaki, Paraskevi
AU - Manoussakis, Emmanuel
AU - Saxoni-Papageorgiou, Photini
AU - Papadopoulos, Nikolaos G.
PY - 2008/5
Y1 - 2008/5
N2 - Background: Although development of clinical tolerance is the rule in allergy to cow's milk (CM), food challenges are required in order to reintroduce CM into the patient's diet. Less 'invasive' procedures able to predict tolerance would be useful as clinical tools. The purpose of this study was to identify potential risk factors for clinical reactivity in CM-allergic children assessed for CM reintroduction. Methods: One hundred and sixteen open challenges performed in children 10-47 months old with IgE-mediated allergy to CM, in order to reintroduce CM into the diet, were retrospectively evaluated. Specific IgE (sIgE) levels assessed by the CAP System FEIA and skin prick tests (SPT) were obtained at diagnosis and prechallenge. Demographic parameters and measures of sIgE were evaluated as potential predictors of a positive challenge in univariate and multivariate logistic regression models. Results: Twenty-four out of 116 challenges were positive, 9 of which required the use of adrenaline. In order of performance, prechallenge sIgE <3.94 kU/l, the combination of SPT and sIgE or an SPT wheal <4 mm could correctly predict a negative challenge outcome, whereas values of SPT >7.5 mm or sIgE >25.4 kU/l, or their combination, had a high positive predictive value. The presence of atopic dermatitis did not affect the predictive accuracy of these values. Conclusions: Milk sIgE level prechallenge is a useful predictor of challenge outcome in patients with milk allergy. SPT do not offer an additional predictive value, but can be used when sIgE is not available.
AB - Background: Although development of clinical tolerance is the rule in allergy to cow's milk (CM), food challenges are required in order to reintroduce CM into the patient's diet. Less 'invasive' procedures able to predict tolerance would be useful as clinical tools. The purpose of this study was to identify potential risk factors for clinical reactivity in CM-allergic children assessed for CM reintroduction. Methods: One hundred and sixteen open challenges performed in children 10-47 months old with IgE-mediated allergy to CM, in order to reintroduce CM into the diet, were retrospectively evaluated. Specific IgE (sIgE) levels assessed by the CAP System FEIA and skin prick tests (SPT) were obtained at diagnosis and prechallenge. Demographic parameters and measures of sIgE were evaluated as potential predictors of a positive challenge in univariate and multivariate logistic regression models. Results: Twenty-four out of 116 challenges were positive, 9 of which required the use of adrenaline. In order of performance, prechallenge sIgE <3.94 kU/l, the combination of SPT and sIgE or an SPT wheal <4 mm could correctly predict a negative challenge outcome, whereas values of SPT >7.5 mm or sIgE >25.4 kU/l, or their combination, had a high positive predictive value. The presence of atopic dermatitis did not affect the predictive accuracy of these values. Conclusions: Milk sIgE level prechallenge is a useful predictor of challenge outcome in patients with milk allergy. SPT do not offer an additional predictive value, but can be used when sIgE is not available.
KW - Cow's milk
KW - Food allergy
KW - Skin prick test
UR - http://www.scopus.com/inward/record.url?scp=43649100511&partnerID=8YFLogxK
U2 - 10.1159/000113519
DO - 10.1159/000113519
M3 - Article
C2 - 18204282
AN - SCOPUS:43649100511
SN - 1018-2438
VL - 146
SP - 156
EP - 161
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
IS - 2
ER -