Reproductive outcomes after in-vitro fertilization

Neelanjana Mukhopadhaya, Sabaratnam Arulkumaran

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)


PURPOSE OF REVIEW: This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy. RECENT FINDINGS: Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertile women who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization. SUMMARY: Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number2
Publication statusPublished - Apr 2007


  • Assisted reproductive technologies
  • In-vitro fertilization
  • Multiple gestation
  • Pregnancy complications


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