Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease

Kleopas A. Kleopa, Kyriacos Kyriacou, Eleni Zamba-Papanicolaou, Theodoros Kyriakides

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19 Citations (Scopus)


We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle.

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalMuscle and Nerve
Issue number2
Publication statusPublished - Feb 2005


  • Anti-gliadin antibodies
  • Ataxia
  • Gluten enteropathy
  • Inclusion-body myopathy
  • Malabsorption
  • Neuropathy


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