seco-cycloartane triterpenes from Gardenia aubryi

Raphaël Grougnet, Prokopios Magiatis, Sofia Mitaku, Stella Loizou, Paraskevi Moutsatsou, Aris Terzis, Pierre Cabalion, François Tillequin, Sylvie Michel

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin 3,8,3′,4′- tetramethyl ether, and conyzatin. The structures of 1 and 2 were established by mass spectrometry and NMR experiments, while the relative configuration of 2 was defined unequivocally using X-ray crystallography. The in vitro cytotoxic activity of compounds 1-3 was evaluated against four human solid tumor cell lines.

Original languageEnglish
Pages (from-to)1711-1714
Number of pages4
JournalJournal of Natural Products
Issue number12
Publication statusPublished - Dec 2006


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