TY - JOUR
T1 - seco-cycloartane triterpenes from Gardenia aubryi
AU - Grougnet, Raphaël
AU - Magiatis, Prokopios
AU - Mitaku, Sofia
AU - Loizou, Stella
AU - Moutsatsou, Paraskevi
AU - Terzis, Aris
AU - Cabalion, Pierre
AU - Tillequin, François
AU - Michel, Sylvie
PY - 2006/12
Y1 - 2006/12
N2 - Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin 3,8,3′,4′- tetramethyl ether, and conyzatin. The structures of 1 and 2 were established by mass spectrometry and NMR experiments, while the relative configuration of 2 was defined unequivocally using X-ray crystallography. The in vitro cytotoxic activity of compounds 1-3 was evaluated against four human solid tumor cell lines.
AB - Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin 3,8,3′,4′- tetramethyl ether, and conyzatin. The structures of 1 and 2 were established by mass spectrometry and NMR experiments, while the relative configuration of 2 was defined unequivocally using X-ray crystallography. The in vitro cytotoxic activity of compounds 1-3 was evaluated against four human solid tumor cell lines.
UR - http://www.scopus.com/inward/record.url?scp=33846463030&partnerID=8YFLogxK
U2 - 10.1021/np060273t
DO - 10.1021/np060273t
M3 - Article
C2 - 17190447
AN - SCOPUS:33846463030
SN - 0163-3864
VL - 69
SP - 1711
EP - 1714
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 12
ER -