TY - JOUR
T1 - Serum CA 125 combined with transvaginal ultrasonography for ovarian cancer screening
AU - Roupa, Zoi
AU - Faros, Efthimios
AU - Raftopoulos, Vasilios
AU - Tzavelas, Georgios
AU - Kotrotsiou, Evangelia
AU - Sotiropoulou, Penelope
AU - Karanikola, Evridiki
AU - Skifta, Evdoxia
AU - Ardavanis, Alexandros
PY - 2004/11
Y1 - 2004/11
N2 - Background: The aim of this study was to evaluate the combination of serum CA125 and Transvaginal Ultra Sonography (TVUS) score, as a screening procedure for ovarian cancer in premenopausal and postmenopausal women. Patients and Methods: A retrospective case-control pilot study was conducted. The files of 120 women with ovarian neoplasia detected by TVUS and increased CA125 level, within the framework of a prevention program, were reviewed. The relationship between the above tests and epithelial malignancy was investigated using the SPSS-12 program for Windows. Results: The combination of CA125 value exceeding 30U/ml and a TVUS score ≥35 had a sensitivity of 81.7% and specificity of 100% in predicting ovarian cancer. Mathematical analysis of the logistic model of our variables revealed a mathematical model that can calculate the likelihood of ovarian cancer detection, by using a combination of CA125≥30U/ml and TVUS score≥35. Conclusion: By combining TVUS and CA125, an accurate prediction for the presence of ovarian cancer may be achieved. Further investigation in a larger population is warranted.
AB - Background: The aim of this study was to evaluate the combination of serum CA125 and Transvaginal Ultra Sonography (TVUS) score, as a screening procedure for ovarian cancer in premenopausal and postmenopausal women. Patients and Methods: A retrospective case-control pilot study was conducted. The files of 120 women with ovarian neoplasia detected by TVUS and increased CA125 level, within the framework of a prevention program, were reviewed. The relationship between the above tests and epithelial malignancy was investigated using the SPSS-12 program for Windows. Results: The combination of CA125 value exceeding 30U/ml and a TVUS score ≥35 had a sensitivity of 81.7% and specificity of 100% in predicting ovarian cancer. Mathematical analysis of the logistic model of our variables revealed a mathematical model that can calculate the likelihood of ovarian cancer detection, by using a combination of CA125≥30U/ml and TVUS score≥35. Conclusion: By combining TVUS and CA125, an accurate prediction for the presence of ovarian cancer may be achieved. Further investigation in a larger population is warranted.
KW - CA 125
KW - Menopausal status
KW - Ovarian cancer screening
KW - Transvaginal ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=11844294937&partnerID=8YFLogxK
M3 - Review article
C2 - 15646829
AN - SCOPUS:11844294937
SN - 0258-851X
VL - 18
SP - 831
EP - 836
JO - In Vivo
JF - In Vivo
IS - 6
ER -
