Severe exacerbation of liver disease during pregnancy in a thalassemic GBV-C/HGV-positive patient and neonatal hepatitis in offspring

Y. Horsmans, P. Karayiannis, J. L. Christophe, J. M. Pickering, C. Debauche, C. Cornu, J. Rahier, G. Hess, H. C. Thomas, A. P. Geubel

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The case of a young woman with GB virus C/hepatitis G virus (GBV-C/HGV) infection and with a severe exacerbation of chronic hepatitis of unknown etiology during pregnancy is described. In the offspring, severe neonatal hepatitis with subsequent mild chronic liver disease of at least 16-month duration was followed by the development of antibodies to the envelope protein (E2) of GBV-C/HGV, suggesting that the child was recovering from GBV- C/HGV infection. There was an improvement in clinical and biochemical parameters in the mother following delivery and alpha-interferon therapy was associated with a transient biochemical response.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalJournal of Medical Virology
Volume57
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Chronic hepatitis
  • Hepatitis G
  • Neonatal hepatitis
  • Pregnancy

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