Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Moran Dvela-Levitt; Maria Kost-Alimova; Maheswarareddy Emani; Eva Kohnert; Rebecca Thompson; Eriene Heidi Sidhom; Ana Rivadeneira; Nareh Sahakian; Julie Roignot; Gregory Papagregoriou; Monica S. Montesinos; Abbe R. Clark; David McKinney; Juan Gutierrez; Mark Roth; Lucienne Ronco; Esther Elonga; Todd A. Carter; Andreas Gnirke; Michelle Melanson; Kate Hartland; Nicolas Wieder; Jane C.H. Hsu; Constantinos Deltas; Rebecca Hughey; Anthony J. Bleyer; Stanislav Kmoch; Martina Živná; Veronika Barešova; Savithri Kota; Johannes Schlondorff; Myriam Heiman; Seth L. Alper; Florence Wagner; Astrid Weins; Todd R. Golub; Eric S. Lander; Anna Greka

doi:10.1016/j.cell.2019.07.002

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Moran Dvela-Levitt
, Maria Kost-Alimova
, Maheswarareddy Emani
, Eva Kohnert
, Rebecca Thompson
, Eriene Heidi Sidhom
, Ana Rivadeneira
, Nareh Sahakian
, Julie Roignot
, Gregory Papagregoriou
, Monica S. Montesinos
, Abbe R. Clark
, David McKinney
, Juan Gutierrez
, Mark Roth
, Lucienne Ronco
, Esther Elonga
, Todd A. Carter
, Andreas Gnirke
, Michelle Melanson

Kate Hartland, Nicolas Wieder, Jane C.H. Hsu, Constantinos Deltas, Rebecca Hughey, Anthony J. Bleyer, Stanislav Kmoch, Martina Živná, Veronika Barešova, Savithri Kota, Johannes Schlondorff, Myriam Heiman, Seth L. Alper, Florence Wagner, Astrid Weins, Todd R. Golub, Eric S. Lander, Anna Greka

Research output: Contribution to journal › Article › peer-review

Abstract

A small molecule shows promise in clearing misfolded proteins by re-routing them toward lysosomal degradation.

Original language	English
Pages (from-to)	521-535.e23
Journal	Cell
Volume	178
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.07.002
Publication status	Published - 25 Jul 2019
Externally published	Yes

Keywords

cargo receptor
COP vesicles
endoplasmic reticulum
epithelial cells
ER stress
Golgi apparatus
kidney
organoids
secretory pathway
unfolded protein response

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10.1016/j.cell.2019.07.002

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Dvela-Levitt, M., Kost-Alimova, M., Emani, M., Kohnert, E., Thompson, R., Sidhom, E. H., Rivadeneira, A., Sahakian, N., Roignot, J., Papagregoriou, G., Montesinos, M. S., Clark, A. R., McKinney, D., Gutierrez, J., Roth, M., Ronco, L., Elonga, E., Carter, T. A., Gnirke, A., ... Greka, A. (2019). Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell, 178(3), 521-535.e23. https://doi.org/10.1016/j.cell.2019.07.002

@article{c33ebebca9e54443bf3fedf42d6ad0a7,

title = "Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy",

abstract = "A small molecule shows promise in clearing misfolded proteins by re-routing them toward lysosomal degradation.",

keywords = "cargo receptor, COP vesicles, endoplasmic reticulum, epithelial cells, ER stress, Golgi apparatus, kidney, organoids, secretory pathway, unfolded protein response",

author = "Moran Dvela-Levitt and Maria Kost-Alimova and Maheswarareddy Emani and Eva Kohnert and Rebecca Thompson and Sidhom, \{Eriene Heidi\} and Ana Rivadeneira and Nareh Sahakian and Julie Roignot and Gregory Papagregoriou and Montesinos, \{Monica S.\} and Clark, \{Abbe R.\} and David McKinney and Juan Gutierrez and Mark Roth and Lucienne Ronco and Esther Elonga and Carter, \{Todd A.\} and Andreas Gnirke and Michelle Melanson and Kate Hartland and Nicolas Wieder and Hsu, \{Jane C.H.\} and Constantinos Deltas and Rebecca Hughey and Bleyer, \{Anthony J.\} and Stanislav Kmoch and Martina {\v Z}ivn{\'a} and Veronika Bare{\v s}ova and Savithri Kota and Johannes Schlondorff and Myriam Heiman and Alper, \{Seth L.\} and Florence Wagner and Astrid Weins and Golub, \{Todd R.\} and Lander, \{Eric S.\} and Anna Greka",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "25",

doi = "10.1016/j.cell.2019.07.002",

language = "English",

volume = "178",

pages = "521--535.e23",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier BV",

number = "3",

}

Dvela-Levitt, M, Kost-Alimova, M, Emani, M, Kohnert, E, Thompson, R, Sidhom, EH, Rivadeneira, A, Sahakian, N, Roignot, J, Papagregoriou, G, Montesinos, MS, Clark, AR, McKinney, D, Gutierrez, J, Roth, M, Ronco, L, Elonga, E, Carter, TA, Gnirke, A, Melanson, M, Hartland, K, Wieder, N, Hsu, JCH, Deltas, C, Hughey, R, Bleyer, AJ, Kmoch, S, Živná, M, Barešova, V, Kota, S, Schlondorff, J, Heiman, M, Alper, SL, Wagner, F, Weins, A, Golub, TR, Lander, ES & Greka, A 2019, 'Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy', Cell, vol. 178, no. 3, pp. 521-535.e23. https://doi.org/10.1016/j.cell.2019.07.002

TY - JOUR

T1 - Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

AU - Dvela-Levitt, Moran

AU - Kost-Alimova, Maria

AU - Emani, Maheswarareddy

AU - Kohnert, Eva

AU - Thompson, Rebecca

AU - Sidhom, Eriene Heidi

AU - Rivadeneira, Ana

AU - Sahakian, Nareh

AU - Roignot, Julie

AU - Papagregoriou, Gregory

AU - Montesinos, Monica S.

AU - Clark, Abbe R.

AU - McKinney, David

AU - Gutierrez, Juan

AU - Roth, Mark

AU - Ronco, Lucienne

AU - Elonga, Esther

AU - Carter, Todd A.

AU - Gnirke, Andreas

AU - Melanson, Michelle

AU - Hartland, Kate

AU - Wieder, Nicolas

AU - Hsu, Jane C.H.

AU - Deltas, Constantinos

AU - Hughey, Rebecca

AU - Bleyer, Anthony J.

AU - Kmoch, Stanislav

AU - Živná, Martina

AU - Barešova, Veronika

AU - Kota, Savithri

AU - Schlondorff, Johannes

AU - Heiman, Myriam

AU - Alper, Seth L.

AU - Wagner, Florence

AU - Weins, Astrid

AU - Golub, Todd R.

AU - Lander, Eric S.

AU - Greka, Anna

PY - 2019/7/25

Y1 - 2019/7/25

N2 - A small molecule shows promise in clearing misfolded proteins by re-routing them toward lysosomal degradation.

AB - A small molecule shows promise in clearing misfolded proteins by re-routing them toward lysosomal degradation.

KW - cargo receptor

KW - COP vesicles

KW - endoplasmic reticulum

KW - epithelial cells

KW - ER stress

KW - Golgi apparatus

KW - kidney

KW - organoids

KW - secretory pathway

KW - unfolded protein response

UR - https://www.scopus.com/pages/publications/85068818334

U2 - 10.1016/j.cell.2019.07.002

DO - 10.1016/j.cell.2019.07.002

M3 - Article

C2 - 31348885

AN - SCOPUS:85068818334

SN - 0092-8674

VL - 178

SP - 521-535.e23

JO - Cell

JF - Cell

IS - 3

ER -

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

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Keywords

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