TY - JOUR
T1 - Steatosis and steatohepatitis in postmortem material from Northwestern Greece
AU - Zois, Christos D.
AU - Baltayiannis, Gerasimos H.
AU - Bekiari, Anna
AU - Goussia, Anna
AU - Karayiannis, Peter
AU - Doukas, Michalis
AU - Demopoulos, Demetrios
AU - Mitsellou, Antigoni
AU - Vougiouklakis, Theodoros
AU - Mitsi, Vasiliki
AU - Tsianos, Epameinondas V.
PY - 2010/8/21
Y1 - 2010/8/21
N2 - AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to define the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece.
AB - AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to define the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece.
KW - Autopsy
KW - Fatty liver
KW - Non-alcoholic liver disease
KW - Steatohepatitis
KW - Steatosis
UR - http://www.scopus.com/inward/record.url?scp=77955946848&partnerID=8YFLogxK
U2 - 10.3748/wjg.v16.i31.3944
DO - 10.3748/wjg.v16.i31.3944
M3 - Article
C2 - 20712056
AN - SCOPUS:77955946848
SN - 1007-9327
VL - 16
SP - 3944
EP - 3949
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 31
ER -