Studies of GB hepatitis agent in tamarins

Peter Karayiannis, Lidija M. Petrovic, Mark Fry, Duncan Moore, Mike Enticott, Michael J. McGarvey, Peter J. Scheuer, Howard C. Thomas

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Three tamarins (Saguinus labiatus), two of which had previously been infected with hepatitis A virus and parenteral non‐A, non‐B hepatitis, were inoculated intravenously with the agent of GB hepatitis. All three animals developed alanine aminotransferase abnormalities 2, weeks after inoculation. Peak alanine aminotransferase levels were recorded 4 weeks postinoculation. These declined thereafter but continued to fluctuate at abnormal levels for 32 weeks. Liver biopsies showed liver cell swelling and inflammation with focal necrosis. Portal tracts and areas around central veins were heavily infiltrated with mononuclear cells. A fourth animal (no previous exposure to hepatitis viruses) inoculated with GB was killed on Day 15 postinoculation. Serum and extracts of liver and feces from this day were used as inocula for three other animals. Only the serum and liver extract transmitted GB hepatitis. The fecal specimen did not transmit and a fecal extract taken at a later date from another animal was also noninfectious. GB hepatitis virus is distinct from the viruses causing Type A and blood‐borne non‐A, non‐B‐hepatitis. Although the virus is present in serum and has previously been transmitted per os, it is not shed in feces.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalHepatology
Volume9
Issue number2
DOIs
Publication statusPublished - 1989

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Hepatitis
Liver Extracts
Hepatitis Viruses
Alanine Transaminase
Feces
Saguinus
Serum
Viruses
Hepatitis A virus
Liver
Veins
Necrosis
Inflammation
Biopsy

Cite this

Karayiannis, P., Petrovic, L. M., Fry, M., Moore, D., Enticott, M., McGarvey, M. J., ... Thomas, H. C. (1989). Studies of GB hepatitis agent in tamarins. Hepatology, 9(2), 186-192. https://doi.org/10.1002/hep.1840090204
Karayiannis, Peter ; Petrovic, Lidija M. ; Fry, Mark ; Moore, Duncan ; Enticott, Mike ; McGarvey, Michael J. ; Scheuer, Peter J. ; Thomas, Howard C. / Studies of GB hepatitis agent in tamarins. In: Hepatology. 1989 ; Vol. 9, No. 2. pp. 186-192.
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Karayiannis, P, Petrovic, LM, Fry, M, Moore, D, Enticott, M, McGarvey, MJ, Scheuer, PJ & Thomas, HC 1989, 'Studies of GB hepatitis agent in tamarins', Hepatology, vol. 9, no. 2, pp. 186-192. https://doi.org/10.1002/hep.1840090204

Studies of GB hepatitis agent in tamarins. / Karayiannis, Peter; Petrovic, Lidija M.; Fry, Mark; Moore, Duncan; Enticott, Mike; McGarvey, Michael J.; Scheuer, Peter J.; Thomas, Howard C.

In: Hepatology, Vol. 9, No. 2, 1989, p. 186-192.

Research output: Contribution to journalArticle

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Karayiannis P, Petrovic LM, Fry M, Moore D, Enticott M, McGarvey MJ et al. Studies of GB hepatitis agent in tamarins. Hepatology. 1989;9(2):186-192. https://doi.org/10.1002/hep.1840090204