Studies of HBV replication during acute hepatitis followed by recovery and acute hepatitis progressing to chronic disease

A. S F Lok, P. Karayiannis, T. P. Jowett, M. J F Fowler, P. Farci, J. Monjardino, H. C. Thomas

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26 Citations (Scopus)

Abstract

The serologic and viral profiles of 24 patients who presented with acute hepatitis B virus (HBV) infection were studied. Although in rare cases, HBV-DNA was detectable before hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), in the majority the viral proteins appeared first. In acute hepatitis followed by recovery, as IgM anti-HBc (hepatitis B core antigen) titres rose, the level of HBV replication fell and serum transaminases became elevated. In patients progressing to chronic HBV infection, IgM anti-HBc titres rose early, viral replication was initially low but continued to rise as the serum transaminase levels became elevated. 7S IgM anti-HBc, although present in the phase of established chronic HBV infection, was not found in the early phase of the chronic infection. Thus this antibody appears to be a consequence of, rather than a causative factor in, chronic HBV infection.

Original languageEnglish
Pages (from-to)671-679
Number of pages9
JournalJournal of Hepatology
Volume1
Issue number6
DOIs
Publication statusPublished - 1985

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