TY - JOUR
T1 - Studies of HBV replication during acute hepatitis followed by recovery and acute hepatitis progressing to chronic disease
AU - Lok, A. S F
AU - Karayiannis, P.
AU - Jowett, T. P.
AU - Fowler, M. J F
AU - Farci, P.
AU - Monjardino, J.
AU - Thomas, H. C.
PY - 1985
Y1 - 1985
N2 - The serologic and viral profiles of 24 patients who presented with acute hepatitis B virus (HBV) infection were studied. Although in rare cases, HBV-DNA was detectable before hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), in the majority the viral proteins appeared first. In acute hepatitis followed by recovery, as IgM anti-HBc (hepatitis B core antigen) titres rose, the level of HBV replication fell and serum transaminases became elevated. In patients progressing to chronic HBV infection, IgM anti-HBc titres rose early, viral replication was initially low but continued to rise as the serum transaminase levels became elevated. 7S IgM anti-HBc, although present in the phase of established chronic HBV infection, was not found in the early phase of the chronic infection. Thus this antibody appears to be a consequence of, rather than a causative factor in, chronic HBV infection.
AB - The serologic and viral profiles of 24 patients who presented with acute hepatitis B virus (HBV) infection were studied. Although in rare cases, HBV-DNA was detectable before hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), in the majority the viral proteins appeared first. In acute hepatitis followed by recovery, as IgM anti-HBc (hepatitis B core antigen) titres rose, the level of HBV replication fell and serum transaminases became elevated. In patients progressing to chronic HBV infection, IgM anti-HBc titres rose early, viral replication was initially low but continued to rise as the serum transaminase levels became elevated. 7S IgM anti-HBc, although present in the phase of established chronic HBV infection, was not found in the early phase of the chronic infection. Thus this antibody appears to be a consequence of, rather than a causative factor in, chronic HBV infection.
UR - http://www.scopus.com/inward/record.url?scp=0021815588&partnerID=8YFLogxK
U2 - 10.1016/S0168-8278(85)80010-6
DO - 10.1016/S0168-8278(85)80010-6
M3 - Article
C2 - 4056361
AN - SCOPUS:0021815588
SN - 0168-8278
VL - 1
SP - 671
EP - 679
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 6
ER -