Subclasses of antibodies to hepatitis B core antigen in chronic HBV infection: Changes during treatment with alpha interferons and predictors of response

G. Chen, P. Karayiannis, M. J. McGarvey, A. M.L. Lever, J. A. McDonald, L. J. Scully, S. Kanatakis, H. C. Thomas

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Abstract

Response to interferon therapy in chronic hepatitis B virus (HBV) carriers is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins, induced by interferon. IgG 1, 2, 3, and 4 class anti-HBc did not change during therapy, but IgG 3 anti-HBc was significantly lower in responders than non-responders. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (p < 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) HBV carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.

Original languageEnglish
Pages (from-to)1123-1128
Number of pages6
JournalGut
Volume30
Issue number8
Publication statusPublished - 1989

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Hepatitis B Core Antigens
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Interferon-alpha
Antibodies
Immunoglobulin Isotypes
Immunoglobulin G
Interferons
Immunoglobulin M
Immunity
HIV
Nucleocapsid Proteins
Nucleocapsid
Antiviral Agents
Anti-Idiotypic Antibodies
Hepatocytes
Therapeutics
Antigens

Cite this

Chen, G., Karayiannis, P., McGarvey, M. J., Lever, A. M. L., McDonald, J. A., Scully, L. J., ... Thomas, H. C. (1989). Subclasses of antibodies to hepatitis B core antigen in chronic HBV infection: Changes during treatment with alpha interferons and predictors of response. Gut, 30(8), 1123-1128.
Chen, G. ; Karayiannis, P. ; McGarvey, M. J. ; Lever, A. M.L. ; McDonald, J. A. ; Scully, L. J. ; Kanatakis, S. ; Thomas, H. C. / Subclasses of antibodies to hepatitis B core antigen in chronic HBV infection : Changes during treatment with alpha interferons and predictors of response. In: Gut. 1989 ; Vol. 30, No. 8. pp. 1123-1128.
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abstract = "Response to interferon therapy in chronic hepatitis B virus (HBV) carriers is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins, induced by interferon. IgG 1, 2, 3, and 4 class anti-HBc did not change during therapy, but IgG 3 anti-HBc was significantly lower in responders than non-responders. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (p < 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) HBV carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.",
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Chen, G, Karayiannis, P, McGarvey, MJ, Lever, AML, McDonald, JA, Scully, LJ, Kanatakis, S & Thomas, HC 1989, 'Subclasses of antibodies to hepatitis B core antigen in chronic HBV infection: Changes during treatment with alpha interferons and predictors of response', Gut, vol. 30, no. 8, pp. 1123-1128.

Subclasses of antibodies to hepatitis B core antigen in chronic HBV infection : Changes during treatment with alpha interferons and predictors of response. / Chen, G.; Karayiannis, P.; McGarvey, M. J.; Lever, A. M.L.; McDonald, J. A.; Scully, L. J.; Kanatakis, S.; Thomas, H. C.

In: Gut, Vol. 30, No. 8, 1989, p. 1123-1128.

Research output: Contribution to journalArticle

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T2 - Changes during treatment with alpha interferons and predictors of response

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AU - Karayiannis, P.

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AU - Thomas, H. C.

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AB - Response to interferon therapy in chronic hepatitis B virus (HBV) carriers is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins, induced by interferon. IgG 1, 2, 3, and 4 class anti-HBc did not change during therapy, but IgG 3 anti-HBc was significantly lower in responders than non-responders. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (p < 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) HBV carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.

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