Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections: changes during treatment with interferons and predictors of response

G. M. Cheng; P. Karayiannis; H. C. Thomas

Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections: changes during treatment with interferons and predictors of response

G. M. Cheng, P. Karayiannis, H. C. Thomas

Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Response to interferon therapy in chronic hepatitis B virus (HBV) carrier is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable, suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins induced by interferon. IgG 1, 2, 3 and 4 did not change during therapy. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (P less than 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.

Original language	English
Pages (from-to)	141-143, 188
Journal	Zhonghua nei ke za zhi [Chinese journal of internal medicine]
Volume	29
Issue number	3
Publication status	Published - Mar 1990

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Cite this

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title = "Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections: changes during treatment with interferons and predictors of response",

abstract = "Response to interferon therapy in chronic hepatitis B virus (HBV) carrier is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable, suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins induced by interferon. IgG 1, 2, 3 and 4 did not change during therapy. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (P less than 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.",

author = "Cheng, \{G. M.\} and P. Karayiannis and Thomas, \{H. C.\}",

year = "1990",

month = mar,

language = "English",

volume = "29",

pages = "141--143, 188",

journal = "Zhonghua nei ke za zhi [Chinese journal of internal medicine]",

issn = "0578-1426",

publisher = "Chinese Medical Journals Publishing House Co.Ltd",

number = "3",

}

Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections: changes during treatment with interferons and predictors of response. / Cheng, G. M.; Karayiannis, P.; Thomas, H. C.
In: Zhonghua nei ke za zhi [Chinese journal of internal medicine], Vol. 29, No. 3, 03.1990, p. 141-143, 188.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections

T2 - changes during treatment with interferons and predictors of response

AU - Cheng, G. M.

AU - Karayiannis, P.

AU - Thomas, H. C.

PY - 1990/3

Y1 - 1990/3

N2 - Response to interferon therapy in chronic hepatitis B virus (HBV) carrier is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable, suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins induced by interferon. IgG 1, 2, 3 and 4 did not change during therapy. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (P less than 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.

AB - Response to interferon therapy in chronic hepatitis B virus (HBV) carrier is preceded by the appearance of IgM class anti-HBc (antibody to hepatitis B core antigen). The temporal relationship and magnitude of the IgM anti-HBc response is variable, suggesting that the antibody is not directly involved in hepatocyte lysis, but is merely a marker of a changed state of immunity to the nucleocapsid proteins induced by interferon. IgG 1, 2, 3 and 4 did not change during therapy. IgG anti-HBc of all subclasses was absent in two Chinese HBV carriers. Lower than normal titres of anti-HBc (P less than 0.001) were detected in human immunodeficiency virus antibody positive (anti-HIV) carriers. These data indicate the presence of altered immunity to the nucleocapsid antigens in these two types of chronic HBV carrier that are known to respond poorly to antiviral therapy.

UR - https://www.scopus.com/pages/publications/0025391822

M3 - Article

C2 - 1698593

AN - SCOPUS:0025391822

SN - 0578-1426

VL - 29

SP - 141-143, 188

JO - Zhonghua nei ke za zhi [Chinese journal of internal medicine]

JF - Zhonghua nei ke za zhi [Chinese journal of internal medicine]

IS - 3

ER -

Subclasses of antibodies to hepatitis B core antigen in chronic HBV infections: changes during treatment with interferons and predictors of response

Abstract

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